The Denver Broncos host the Indianapolos Colts on Sunday Night Football in what is expected by oddsmakers to be the most heavily bet NFL game in Week 1.
The Broncos (-7.5 at most books monitored by OddsShark.com) will be out for revenge, especially former Colts quarterback Peyton Manning, who lost to his former team at Indianapolis last year 39-33 as six-point road favorites.
This year, the Broncos look to break their 0-6 SU and ATS streak against the Colts.
That number could climb later in the weekend as bettors look to capitalize on successful early games, especially with the lack of marquee matchups on Monday Night Football.
Odds Shark Computer Prediction: 34-27 Denver
Both teams had a rough week off the field, as Denver wide receiver Wes Welker was banned four games by the NFL for use of amphetamines and Indianapolis owner Jim Irsay was suspended six games and fined $500,000 for pleading guilty to a misdemeanor DWI charge.
During the offseason, Denver signed defensive end DeMarcus Ware to pair with pass-rushing linebacker Von Miller, who missed much of last season due to a suspension and knee injury. The pair will be tasked with containing Indianapolis QB Andrew Luck.
From a trends perspective, the Broncos have a huge edge. The Colts are 0-6 against the spread in their last six season openers while Denver is 5-1 ATS in its last six times opening the year at home.
For moneyline players, the Broncos are 16-2 straight-up in their last 18 games as home favorites, and the Colts are 4-19 SU in their past 23 as road underdogs.
One of the few positive trends for Indianapolis can be disregarded, as the team is 6-0 SU and ATS in the last six meetings with Denver.
The favorite is also 6-2 ATS in the past eight head-to-head matchups between the teams.