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NFL odds: Panthers host Lions, Pats hit the road in Week 2's key games

Week 2's key games pose some interesting betting lines to take advantage of. For those brave enough to bet against the defending champions in the Seahawks-Chargers matchup, San Diego could be a good value pick at plus-5.5 at home.

The New England Patriots are 10-0 straight up in their last 10 games against NFC North opponents. The Patriots will try to extend that winning streak to 11 on Sunday as a three-point road favorite over the Minnesota Vikings, according to sports books monitored by OddsShark.com.

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The Vikings are just 1-7 straight up and against the spread in their last eight games against AFC East opponents. This spread appears to be a bit of an overreaction to Week 1, in which Minnesota steamrolled St. Louis 34-6 as a 2.5-point underdog and New England lost to Miami 33-20 after entering as a 3.5-point favorite. Look for the Patriots to bounce back with a win and cover this week in Minnesota.

The Carolina Panthers are a 2.5-point favorite hosting the Detroit Lions this Sunday. Cam Newton is expected to start for the Panthers, who are 7-0 straight up and 6-0-1 against the spread in their last seven regular season home games. Detroit is 0-3 SU and ATS in its last three road games and 0-4 SU and ATS in its last four games against NFC South opponents.

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For those brave enough to bet against the defending champions in Sunday afternoon's Seahawks-Chargers matchup, San Diego could be a good value pick at plus-5.5 at home. The Chargers are 9-4 against the spread and 8-5 straight up in their last 13 games as home underdogs, and while Seattle is 6-1 straight up and 5-2 against the spread in its last seven games as a road favorite, the Seahawks have fared poorly in their last 13 road games against AFC opponents, with a 1-12 SU and a 2-10-1 ATS record.

The Atlanta Falcons are going off at plus-5 on the road against the Cincinnati Bengals. Atlanta came up with a big home win over New Orleans last week but is 0-7 straight up and 2-5 against the spread in its last seven games as a road underdog. Cincinnati, on the other hand, is 7-0 straight up and against the spread in its last five games as a favorite of five points or more, making the Bengals look like a solid pick at home on Sunday.