Picks, predictions and betting lines for several key Week 3 matchups, including Saints vs. Vikings, Patriots vs. Raiders and Colts vs. Jaguars.
The Indianapolis Colts are a seven-point road favorite over the Jacksonville Jaguars. The Colts are 3-0 straight up and against the spread in their last three games against Jacksonville, winning each game by at least 17 points. The Jaguars are just 1-8 straight up and 2-6-1 against the spread in their last nine games at home. Indianapolis needs a win to bounce back from a disheartening 0-2 start and should get back on track in Jacksonville.