NFL odds: Previewing Eagles-49ers, Giants-Redskins, more Week 4 games

NFL Odds Week 4: Are the unbeaten Philadelphia Eagles favored to beat the San Francisco 49ers?
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The Philadelphia Eagles are unbeaten so far this season, while the San Francisco 49ers have managed to pull out just one win in their first three games. But Colin Kaepernick and company are pegged as the favorites on the opening odds in their marquee Week 4 matchup against the Eagles.

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Philadelphia sits at 3-0 SU and 2-1 ATS on the season after scoring a comeback win over the Jaguars in Week 1 and beating the Colts in Week 2 before sneaking past Washington (but just failing to cover the spread) in Week 3. However the Week 4 opening NFL odds at sportsbooks monitored by have them listed as 4.5-point underdogs on the road against the Niners.

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San Francisco is 1-2 both SU and ATS on the season after following up a Week 1 win in Dallas with back-to-back losses vs. Chicago and at Arizona. The 49ers came out on top the last time they faced the Eagles back in 2011, winning 24-23 as a 10-point road underdog in that contest. Philadelphia had been 5-0 both SU and ATS in their previous five meetings, according to the OddsShark NFL Database, with the OVER paying out for totals bettors in seven of the last eight Eagles vs. Niners matchups.

The Eagles, along with the Bengals and the Cardinals, are the only undefeated teams left in the NFL, with the latter two sitting out Week 4 on byes. The Chargers are 2-1 SU on the season but join the Bengals as the only 3-0 ATS teams through three weeks; San Diego opened as a 13.5-point favorite against 0-3 SU and ATS Jacksonville on the Week 4 odds.

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The New York Giants are six-point underdogs in Washington for Thursday Night Football this week according to sportsbooks monitored by, with the UNDER having paid out for totals bettors in each of the last five games between those two NFC East teams. New York managed to go 2-0 both SU and ATS against Washington last season.

Rounding out the opening NFL Week 4 odds for Sunday are Green Bay at Chicago (-1.5), Buffalo at Houston (-3), Tennessee at Indianapolis (-6.5), Carolina at Baltimore (-2.5), Detroit at the Jets (pick 'em), Tampa Bay at Pittsburgh (-8), Miami vs. Oakland (+3.5) in London, Atlanta at Minnesota (+2.5) and New Orleans at Dallas (+2.5). The Patriots open as three-point road favorites over the Chiefs for the Monday night game in Kansas City.