Wayne missed last week's game against the Pittsburgh Steelers with an elbow injury.
Colts linebacker Erik Walden is out after injuring his quad in the loss to the Steelers.
The Giants announced on Saturday that starting running back Rashad Jennings (knee) and defensive tackle Cullen Jenkins (calf) would miss the game, so the most interesting note was that starting cornerback Dominique Rodgers-Cromartie was active for the game. He was limited in the two games before the bye week and was listed as questionable for the game.
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