The Panthers opened as a 5.5-point favorite, but the line has climbed as high as -7.5 at sportsbooks monitored by OddsShark.com. The moneyline has Carolina between -270 and -330, and Indianapolis between +235 and +250. The Colts, who hold a slim lead over the Houston Texans in the AFC South despite being dead last in yards allowed per game, are 3–4 straight up, 2–5 against the spread and 1–2 ATS on the road in 2015. In their last eight Monday Night Football games on the road, Indianapolis is 6–2 ATS.
The Colts will be without center Khalid Holmes on Monday, who has been ruled out with a neck injury. However, the name not on the injury report that is the big story—QB Andrew Luck, who missed two games earlier this season with a shoulder injury, has been playing with multiple cracked ribs, according to a report on Sunday. If that is the case, the Colts could be fined money or draft picks for not disclosing the injury. The injury would go a long way in explaining Luck’s struggles this season.
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The Panthers are 6–0 SU, and 5–1 ATS, holding a one game lead in the NFC South. The Panthers' only ATS loss this season came at home in Week 3 against the New Orleans Saints. They enter the game leading the NFL in rushing yards per game.
The Panthers are likely to be without center Ryan Kalil and linebacker Shaq Thompson. They are both listed as doubtful, having sat out all three days of practice this week. Fernando Velasco and A.J. Klein will likely start in place of Kalil and Thompson, respectively.
The point total is set at 46.5 points at the sportsbooks. The total has gone UNDER in six of the Colts' last eight road games. It has gone UNDER in seven of the Panthers' last nine home games. The OddsShark Computer predicts a 28.3-17.3 Panthers victory. That would provide for a comfortable Panthers cover, and the UNDER.