Tom Brady and the Patriots are huge road favorites against the Giants, while the Bills find themselves road underdogs against the Jets in their divisional matchup.
The Patriots sit as 8-point favorites against the Giants on the early Week 10 betting lines at sportsbooks monitored by OddsShark.com. The Giants have been bigger home underdogs only three times since 1998, going 0-3 straight up and 2-1 against the spread in those contests.
Meanwhile, the Jets and Bills will face off at MetLife Stadium on Thursday Night Football. The Bills are 0-3 straight up and against the spread in their last three games after a win, and find themselves as 2.5-point underdogs on the road.
The Steelers find themselves in familiar territory, without their starting quarterback Ben Roethlisberger again this upcoming week. Landry Jones steps in under center and Pittsburgh find themselves as 4.5-point favorites over the lowly Browns, who have quarterback issues of their own.
The disappointing Ravens hope to turn the corner after their bye week, as they’ve been installed as 5.5-point home chalk to the Jaguars. The Ravens are 11-2 straight up and against the spread in their last 13 games after the bye.
Two of the most intriguing matchups of the week are divisional battles. Seattle and Arizona are both coming off a bye week, and meet up in a pivotal matchup in Seattle on Sunday Night Football. The Seahawks are 8-1 SU in their last nine games in November according to the OddsShark NFL Database, and are laying three points in this one.
Over in the AFC, Peyton Manning and the Broncos welcome the Chiefs to town, who will be looking to avenge their loss to Denver earlier in the season. The Broncos are 10-0 SU and 8-2 against the spread in their last 10 games after losing as favorite.