Norm Hall/Getty Images

The Arizona Cardinals are 10-point favorites over the lowly 49ers heading into Week 12 of the NFL season. 

By OddsShark
November 25, 2015

The biggest line on the board for Sunday's NFL action sees the Arizona Cardinals as a 10-point road betting favorite against the San Francisco 49ers at sportsbooks monitored by

This marks the first time since 2006 that San Francisco has been a double-digit home underdog. It's also the first time since 2009 that Arizona has been a double-digit favorite against the 49ers according to the OddsShark NFL Database.

The closest line of the day has the Atlanta Falcons as a one-point home favorite against the Minnesota Vikings. Atlanta has failed to cover their last six games, and is 2-4 straight up in that span. Minnesota failed to cover in a 30–13 loss to Green Bay last week, snapping an eight-game against the spread win streak.

Atlanta is 2-4 straight up and 2-3-1 against the spread in its last six home games against Minnesota.

Week 12 Power Rankings: Dangerous Seahawks climb back into top 10

The Seattle Seahawks are a 3.5-point favorite at home against the Pittsburgh Steelers. The Seahawks defense has struggled this season and the offense will be without Marshawn Lynch, who had sports hernia surgery. Of course, Thomas Rawls rushed for 209 yards against the 49ers, so the Seahawks are likely comfortable with the switch.

The Houston Texans are a field goal favorite as they host the new-look New Orleans Saints. New Orleans fired defensive coordinator Rob Ryan during their bye week. It remains to be seen if that will help the defense, but Brian Hoyer will get a crack at it, having been cleared through the concussion protocol.

The Saints are 0-2-1 against the spread in their last three games, while the Texans have won and covered three straight games.

There are three other road favorites on Sunday. The New York Giants are a field goal favorite over Washington in a huge divisional matchup. The Giants have won five straight straight up and against the spread in this rivalry.

The Oakland Raiders are favored by between one and two points on the road against the Tennessee Titans. The Raiders have lost three straight, and failed to cover in their last two games. The Titans have failed to cover three of their last four games.

Sunday wraps up with the Denver Broncos hosting the New England Patriots on Sunday Night Football. The Broncos are a field goal underdog in Brock Osweiler’s second start. The Patriots are 5-1 straight up and against the spread in the last six games between these two teams.