Luck will miss his second straight game with a lacerated kidney and partially torn abdominal muscle. Castonzo will miss his first game since 2011 with a sprained right medial collateral ligament.
Inside linebackers Jerrell Freeman (ribs), D'Qwell Jackson (hamstring) and Sio Moore (back), cornerbacks Vontae Davis (hamstring) and D'Joun Smith (knee) and running back Frank Gore (ankle) are all listed as probable.
Indy (5-5) hosts Tampa Bay (5-5).
AP NFL website: www.pro32.ap.org and http://twitter.com/AP-NFL