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When the Rams returned to Los Angeles in 2016, the NFL finally got its own version of the Bay Area-Los Angeles rivalry back. So far, the series hasn’t disappointed as both teams have three wins against the other. This weekend’s matchup looks like it will be another classic. It's just too bad that the NFL didn't wise up and flex this game into Sunday night.

The 49ers enter the game leading the division with a 4-0 record, and of course, the Rams are the defending NFC West Champions. Not only would a 5-0 start be a big step in the right direction for San Francisco’s playoff chances, but also significantly diminish a hated rival’s. However, accomplishing this feat will be a very difficult task for the Red and Gold.

Get after the quarterback

The biggest mismatch working in San Francisco’s favor is the team’s pass rush versus Los Angeles’ offensive line. According to Pro Football Focus, no quarterback has faced more pressure than Jared Goff this season, and the team ranks 30th in pass blocking. Meanwhile the 49ers pass rush ranks fifth and averages 3.2 sacks per game (ranks tied for sixth).

In week four, the Buccaneers were able to get after Goff for two sacks and nine quarterback hits. Tampa Bay’s pass rush clearly had an impact on the passer as the game was his worst performance of the season.

Slowing down the Ram’s offense is extremely difficult because typically, there aren’t a lot of favorable matchups for the defense. Opposing teams have to take advantage of any mismatch, or the defending NFC Champions will light up the scoreboard. Dee Ford, Nick Bosa, DeForest Bucker, and company will need to be on their “A-game” if the Red and Gold are going to remain undefeated.

Max Protection, Max Protection, and More Max Protection

This season has not been very kind to the 49ers offensive tackles. Joe Staley went down in week two and earlier this week the team announced Mike McGlinchey will miss four-to-six weeks with a knee injury. Making matters even more dire, this is probably the worst week for a team to be without its starting tackles.

Along Los Angeles’ defensive line is a guy who is pretty good at tackle football, Dante Fowler. Among edge defenders, the University of Florida product is tied for fourth with 30 quarterback pressures, and has revived his career with the Rams. In the last couple games, replacement Justin Skule has performed well at left tackle, but adding McGlinchey to the injury report means San Francisco will need to be more creative with its protection plan.

Also number 99 is no slouch either, and performs at a high level regardless of who is lined up in front of him. Expect to see a lot of seven or eight man protection schemes, and chip blocks by running backs and receivers on Sunday.

Innovative Shanahan

Kyle Shanahan is widely considered one of the best offensive minds in football. The young head coach has lived up to his reputation, however, this weekend might be his biggest challenge yet.

Along with the injuries above, fullback Kyle Juszcyk will miss the next month of the season. With so many key pieces missing from the offense, Shanahan needs to take a deep dive into his playbook. At least a few gadget plays to get San Francisco’s weapons in space could go a long way.

Even emphasizing the hurry-up offense with some quick game will help slow down the pass rush. It's a good way to tire out a defense and keep Jimmy Garoppolo clean. Sunday will be an uphill battle for Kyle Shanahan, but he is more than capable to devise a way ot overcome the injuries.