Indianapolis Colts quarterback Jacoby Brissett has been ruled out for Sunday’s home game against the Miami Dolphins.

The team announced the decision earlier Saturday that Brissett, who suffered a left MCL knee sprain in last week’s loss at Pittsburgh, would be among the inactives. Head coach Frank Reich said during the week that Brissett, who was limited in practice, wouldn’t be 100 percent if he played.

Backup Brian Hoyer will get the start. He threw a career-high three TD passes but also had a pick-six and lost fumble against the Steelers after Brissett exited in the second quarter. Brissett was injured when All-Pro offensive guard Quenton Nelson was shoved back into the passer’s left leg.

In a related move, the Colts promoted quarterback Chad Kelly from the practice squad to back up Hoyer.

The Colts (5-3) are 10-point favorites against the Dolphins (1-7). A victory would move the team into a tie for first place in the AFC South Division with the Houston Texans (6-3), who have a bye weekend off.

Brissett has been efficient in completing 64.8 percent of his passes for 1,649 yards with 14 TDs and just three interceptions.

The Colts are also banged up at wide receiver, which prompted another roster move as Marcus Johnson was promoted from the practice squad and second-year pro Deon Cain was waived. Cain had four catches for 52 yards in addition to drawing a couple pass-interference penalties on deep balls this season, but also dropped two passes against the Steelers.

The former fifth-round pick, lost for his rookie year to a preseason knee injury, could be re-signed to the practice squad after the weekend.

Johnson caught six passes for 102 yards and one TD in five games for the Colts last season before suffering a season-ending ankle injury. He debuted in 2017 for the Philadelphia Eagles with five receptions for 45 yards in 10 games.