The debut of new head coach Dan Campbell and the 2021 edition of the Detroit Lions will be much anticipated.
The game will take place on Sunday, September 12, at 1 p.m (ET), and will be televised on Fox.
Detroit is coming off of a disappointing 5-11 season that saw general manager Bob Quinn and head coach Matt Patricia be dismissed, following the team's annual Thanksgiving Day game.
The 49ers drafted quarterback Trey Lance with the No. 3 overall pick in the 2021 NFL Draft, and are looking to rebound following a disappointing 6-10 season.
Former 49ers defensive coordinator Robert Saleh was hired by the N.Y. Jets, leaving many question marks for a defense that was ravaged by injuries in 2020.
It is expected that quarterback Jimmy Garoppolo will be under center to start the season, but it may not take too long for Lance to take the field during his rookie campaign.
For Detroit, Campbell & Co. are preparing for six games against divisional opponents, four games against teams from the NFC West, four games against teams in the AFC North and two games against teams from the two remaining divisions in their own conference. The Denver Broncos will be the Lions' 17th opponent this season.
More from SI All Lions: