Tom Brady makes his anticipated return to the field the same night Terrell Owens makes his Bills debut, with both teams featuring classic AFL uniforms in Foxboro.
2 of 17Peter Read Miller/SI
The Cowboys debut their billion-dollar stadium against Eli Manning and their ancient NFC East rivals under NBC's Sunday Night lights.
3 of 17AP
The Cardinals return to prime time for the first time since its electrifying performance in the Super Bowl. Across the field, Peyton Manning and the always dangerous Colts await.
4 of 17Bob Rosato/SI
The Chargers make their third trip to Heinz Field in less than 12 months, and the Steelers will be favored to make it three-for-three.
5 of 17David Bergman/SI
The rematch of their Week 17 showdown last season, which ended the Jets career of both Brett Favre and Eric Mangini, and put the Chad Pennington-led Dolphins into the playoffs for the first time since 2001.
6 of 17Damian Strohmeyer/SI
The Titans are 1-3 against the Patriots since 2001, but are due for a breakthrough. They'll be battle-tested coming in, having opened the season against the Steelers and having played the Colts in Week 5.
7 of 17John Biever/SI
The past two Super Bowl representatives from the NFC meet in a rematch of the Giants' 37-29 win last November.
8 of 17David E. Klutho/SI
Call it Jake Delhomme's redemption. The Panthers QB will be eager to make up for the egg he laid in last season's NFC Divisional Playoffs.
9 of 17Bob Martin/SI, David Bergman/SI
Eli Manning and Philip Rivers were traded for each other on Draft Day 2004 and this will be their first meeting as starters (Chargers and Giants met in '05, but Rivers didn't play).
10 of 17Bob Rosato/SI
On a Thursday night stage, Niners coach Mike Singletary gets to coach against the franchise he helped to its only Super Bowl title.
11 of 17Rich Gabrielson/Icon SMI
This will be the Chargers' first trip to Denver since the infamous Ed Hochuli call last September.
12 of 17Simon Bruty/SI
The Ravens, who lost three times to the Steelers last season, have to wait 12 weeks before getting a crack at the defending champions.
13 of 17Elsa/Getty Images
Josh McDaniels and Matt Cassel helped each other's stock skyrocket last season in New England. Now they're division enemies, with McDaniels coaching the Broncos and Cassel piloting the Chiefs.
14 of 17Peter Read Miller/SI, Damian Strohmeyer/SI
Interesting cross-conference matchup will feature NFL mega-stars Tony Romo and LaDainian Tomlinson meeting for the first time.
15 of 17Jim McIsaac/Getty Images
If past performance holds up, this game will be a defensive slugfest that NFL purists won't want to miss.
16 of 17AP
Beloved as an Eagle, new Bronco safety Brian Dawkins returns to Philly, where the crowds will cheer him as loudly as they've jeered the front office for letting him go.
17 of 17Chris Livingston/Icon SMI
You could pick pretty much any divisional matchup in the final week of the season, as this contest could go decide the NFC South champion.
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