Kellyn Acosta was set to make his competitive debut for the United States, starting at left back in Friday's World Cup qualifier at St. Vincent and the Grenadines.
The 21-year-old FC Dallas defender was part of the U.S. roster at last year's Under-20 World Cup. He made his national team debut on Jan. 31 against Iceland and played his only other senior national team match against Canada on Feb. 6.
Yedlin was part of a 4-4-2 formation for Friday's match at Arnos Vale, with Brad Guzan in goal, DeAndre Yedlin at right back and Geoff Cameron and Matt Besler in central defense. The U.S. Soccer Federation said just before kickoff that Besler's wife, Amanda, gave birth to Parker Besler earlier Friday.
Kyle Beckerman was in midfield with Alejandro Bedoya, Graham Zusi and Fabian Johnson. Jozy Altidore returned from a hamstring injury for his first national team start since March and was paired in the attack with Bobby Wood.
Captain Michael Bradley (yellow card accumulation) and defender Michael Orozco (red card in Copa America third-place game) were suspended for the match. Forwards Clint Dempsey (irregular heartbeat) and Gyasi Zardes (broken bone in right foot) also missed the game along with midfielder Jermaine Jones (knee) and defender John Brooks (back).
The United States (2-1-1) was in position to clinch advancement to the final round of North and Central American and Caribbean qualifying with a win at St. Vincent (0-4) and a victory by Trinidad and Tobago (3-0-1) against visiting Guatemala (2-2) later Friday. The U.S. hosts Trinidad on Tuesday at Jacksonville, Florida, in its semifinal round finale.
U.S. coach Jurgen Klinsmann said Tim Howard will start in goal on Tuesday.