Appearing on The Debate on Sky Sports, Wise was sceptical when asked whether Liverpool could achieve success with German goalkeeper Karius in the team.
Loris Karius— Jez (@YourMateJez) February 11, 2018
8 clean sheets
Pretty decent numbers for a guy who’s apparently not good enough.
Starting to see the man with the big reputation in Germany. Seen as a future Germany #1 and you can see why, quality outing from our main man @LorisKarius #LK1 pic.twitter.com/7UUxkC4QLZ
“I am not 100 per cent sure," was Wise's response. "I look at the back four. I am not convinced about Lovren.
"Matip is slightly better. Certain positions at the back is where I would be a little bit worried.”
Karius joined Liverpool from Mainz for £4.7m in 2016, which was seen as a coup after he was named as the second-best goalkeeper in the Bundesliga the previous season. Only Bayern Munich's Manuel Neuer ranked higher.
But the 24-year-old has failed to impress at Anfield, and many observers remain unconvinced by his abilities. Steve Sidwell, who appeared alongside Wise on The Debate, suggested that Stoke's Jack Butland may be a better alternative to Jurgen Klopp's current options.
Lovren has been with Liverpool for four seasons now and has made 130 appearances for the Reds in that time, but he too has often come in for criticism. The recent acquisition of Virgil van Dijk appears to be rubbing off well on the Croatian though.
Van Dijk has transformed Lovren. Anyone who doesn't think Lovren's been amazing is lying.— Empire of the Kop (@empireofthekop) February 14, 2018
There may be some truth in what Wise says, as Liverpool are likely to finish this season trophyless, for the sixth consecutive year. They were knocked out of the FA Cup by West Brom and are outsiders to win the Champions League. They are also 18 points behind dominant league leaders Manchester City.
The Reds' primary ambition this season is to retain their place in the top four. That quest continues when they host West Ham at Anfield next week.