The French center back will miss key games in the league, Copa del Rey and Champions League.
Real Madrid defender Raphael Varane is set to be out of action for the next month due to a muscle problem, dealing recently appointed caretaker manager Santiago Solari an early blow.
The 25-year-old was substituted at halftime during Madrid's recent 5-1 defeat to Barcelona after feeling discomfort in his leg, believed to have stemmed from his foul on Luis Suarez in the penalty area in the buildup to Barca's second of the game.
As a result, Spanish media outlet AS claim the center back will be out of action for the next month due to pain in his left adductor muscle, potentially ruling the Frenchman out of Los Blancos' next six games.
Varane is set to miss the Copa del Rey first leg against Melilla, La Liga games against Real Valladolid, Celta Vigo and Eibar, as well as Champions League fixtures against Viktoria Plzen and Roma, with the defender potentially available for selection against Valencia in December.
Real Madrid are already without Jesus Vallejo, as a thigh injury ruled the 21-year-old out of the recent Clasico, meaning Los Blancos have only Sergio Ramos and Nacho as their recognized first team center backs.
Also set for time on the sidelines is striker Mariano Diaz, who is set to miss games against Melilla, Real Valladolid and Viktoria Plzen, with a hamstring injury ruling him out for the next 10 games.
Real Madrid have endured a poor start to the season, as they're already seven points behind Barcelona at the top of La Liga and have only one win from their last seven games in all competitions.