Mauricio Pochettino will be without three first-team players for Tottenham's trip to the Emirates on Sunday, but is hopeful of welcoming back two long term absentees.
Davinson Sanchez, Victor Wanyama and Mousa Dembele have all been ruled out of Sunday's clash due to ongoing injury issues. However, after featuring in the matchday squad against Inter during the week, left-back Danny Rose is hopeful of a return to the pitch at the weekend.
The Evening Standardreport that Kieran Trippier, who hasn't played since before the recent international break, will undergo a late fitness test, but the north London derby will likely come too early for the English international.
Tottenham go into Sunday's match on a back of a six game winning streak, including impressive home wins against Inter and Chelsea. Pochettino was buoyed by the return of Belgian international Jan Vertonghen against Inter during the week, who put in an excellent defensive performance alongside his compatriot Toby Alderweireld.
However, Pochettino's squad has been ravaged by injury this season, not least due to the strong Tottenham representation at this summer's World Cup. The Argentine has spoken in the past of the difficulty of managing his late-returning World Cup stars, stating he had an 'impossible' task.
Despite much of the squad undergoing a foreshortened pre-season schedule, Tottenham go into Sunday's derby three points ahead of their north London rivals. Should Spurs take the opportunity to go six points clear of their rivals come Sunday night, they will be full of confidence going into their hectic Christmas schedule.
After what has been a potentially season-changing week for Pochettino, a win at the Emirates will put his side in a very healthy position to secure Champions League football next term.
In addition, six of Tottenham's next nine league opponents after the derby currently sit in the bottom half of the Premier League, meaning Spurs will be favourites to maintain their top four position come the turn of the year.