It has been an injury hit season for the Blues this term, and they will continue to miss a few of their star players for the Manchester United visit.
Frank Lampard confirmed in his pre-match press conference that midfielder N'Golo Kante and defender Antonio Rudiger would both be unavailable.
The Frenchman is still recovering from his groin injury, which has seen the 28-year-old only play four times in the Premier League this season.
Whilst Antonio Rudiger is back in training from his groin problem, but is not yet ready to head back into the first-team just yet.
Lampard did hint that there could be rotation amongst the Blues' ranks on Wednesday as he looks to give the fringe players game time ahead of the busy schedule coming up as all the competitions come into full swing.
"I’ve got to be aware that we haven’t changed that much. This game may see opportunities for players who haven’t been getting minutes," Lampard said at Cobham ahead of the clash with Manchester United.
Meanwhile, nothing was mentioned on Ross Barkley or Andreas Christensen, who both missed the 4-2 victory over Burnley on Saturday.
Barkley is expected to be in contention for the cup tie, but Andreas Christensen is set to remain out for the Blues.
Pedro could come back into the first-team fold along with Olivier Giroud, who have both had to settle for places on the bench due to the form of the wide-men [Willian, Christian Pulisic, Callum Hudson-Odoi] and the formidable Tammy Abraham
Chelsea host Manchester United at Stamford Bridge in the Carabao Cup last-16 for a spot in the quarter-finals on Wednesday.