Reading's new loanee Matt Miazga has only been able to make the bench after joining on loan from Chelsea, who are the Royals' opponents today.
Former Blue John Swift also faces his old club.
New signing João Virgínia starts for the hosts, as Tyler Blackett starts also for the hosts.
Here's Reading's line-up in full:
Meanwhile for the Blues, Willy Caballero starts in net ahead of Kepa Arrizabalaga.
Fikayo Tomori and Andreas Christensen start at the back for the Blues in the heart of defence.
Olivier Giroud gets the nod up top, with Ross Barkley and Christian Pulisic also starting.
Here's Frank Lampard's starting XI in full: