Liverpool have a two-goal advantage over RB Leipzig ahead of the second leg in Budapest.
Two mistakes from the Germans played into the hands of the critical finishing of Mohamed Salah and Sadio Mane.
Jurgen Klopp's side will be hoping that they can put their Premier League form behind them and bounce back following Sunday's 1-0 defeat to struggling Fulham.
Despite the first leg being held at a neutral venue, Julian Nagelsmann's side had the 'home' tie, but with the two goals, that means two away goals for the Reds.
With the coronavirus restrictions, both legs have been played in Budapest.
The Premier League holders made seven changes prior to their fifth straight loss at home.
Tonight's visitors' momentarily went top of the Bundesliga with a 3-0 away win over Freiburg extending the winning run to four.
This season would be over for Liverpool if they fail to make it through to the next stage.
Liverpool Team News
The six-time winners made five changes.
Starting Line-Up: Alisson; Alexander-Arnold, Phillips, Kabak, Robertson; Fabinho, Wijnaldum, Thiago; Salah, Jota, Mane.
Subs: Adrian, H. Davies, Milner, Keita, Oxlade-Chamberlain, Jones, Tsimikas, Shaqiri, B. Davies, R. Williams, N.Williams