Real Madrid full-back Lucas Vasquez is the latest name to be ruled out of the Champions League second leg for Zinedine Zidane's side.
The 29-year-old was forced off during their 2-1 win over Barcelona on Saturday evening.
He joins a growing injury list for the 13-time European Cup winners, despite this they still saw off the Reds in the first leg.
Vinicius Jnr's brace and Marco Asensio's goal gave Los Blancos a two-goal lead going into the return leg at Anfield, with Liverpool scoring an away goal through Mohamed Salah.
Sergio Ramos missed the first leg as did defensive partner Raphael Varane after the Frenchman returned a positive Coronavirus test prior to the game.
Ramos' muscular problem will also see him miss the second leg on Merseyside, similarly with Varane as the game comes too soon in his recovery from illness.
First Leg Coverage
The Real Madrid full-back, Vasquez, suffered a torn posterior cruciate ligament (PCL) in his left knee.
An injury that not only has prematurely ended his season but also spells the end of his Madrid career with the Spaniard's contract expiring in June.
Federico Valverde made a 20-minute cameo appearance on Tuesday however he is also a doubt.
Liverpool require two unanswered goals in order to progress to the Champions League semi-final where they could face either FC Porto or Chelsea.
Chelsea have a 2-0 lead over the Portuguese side as Mason Mount and Ben Chillwell netted two crucial away goals in Seville.
There is no news surrounding Liverpool's injury problems yet with no clarity whether Curtis Jones will be fit to face Real Madrid after the Liverpudlian missed the 2-1 win over Aston Villa with a muscle problem.