Bautista, who has 15 home runs this season, exited in the third inning with left leg tightness, while Lawrie, who has 12 homers this year, fractured his right index finger and is likely headed to the disabled list, according to MLB.com's Gregor Chisholm.
Bautista will have an MRI on Monday, Chisholm reports. He injured himself after laying a bunt down the third-base line with two runners on base.
Lawrie was hit by a pitch on the finger in the second inning — a 92 mph fastball from Reds starter Johnny Cueto.
Bautista, 33, is hitting .305 with 49 RBIs in 77 games, while the 24-year-old Lawrie is hitting .244 with 38 RBIs.
The Blue Jays (42-34) have lost five of six.