Like the girl with the curl, Roddick tends to very good or horrid in New York. He won the U.S. Open in 2003, then suffered a shocking first-round loss to unknown Gilles Muller in `05. With Jimmy Connors serving as his coach, Roddick rebounded to reach the final last year. Barring another upset, he could get his rematch with Roger Federer in the quarterfinals this year.
2 of 12Manny Millan/SI
Regardless of her ranking, match preparation or her fitness level, Serena is a simply a threat to win every time she enters a major. She's won the U.S. Open twice and triumphed at the last hard-court major in '07, the Australian Open.
3 of 12Bob Martin/SI
Like her sister, Venus is a two-time champ in New York. And like her sister, she has an uncanny talent for summoning her best tennis at the biggest events. Seeding be damned, the '07 Wimbledon champ is a player no one else will want to face.
4 of 12Chuck Solomon/SI
Like Roddick, Blake favors the Open over the other Slams. With his personal Connecticut cheering section -- the J Block -- looking on, Blake reached the quarterfinals in both '05 and '06. But he has hit the skids so far in '07 -- can he rebound in Queens?
5 of 12Clive Brunskill/Getty Images
Once a top-20 player, Fish has been beset by injuries this year, including an ankle he sprained kicking field goals. Still, he is a strong hard court player and, earlier this year, reached the Australian Open quarterfinals.
6 of 12AP
Lanky, laid-back Californian has had an uneven sophomore season. The high point came in early August, when he set an ATP record with 10 straight aces in an upset of Blake on his way to the Indianapolis semis. On his serve alone, he could sail into the middle weekend.
7 of 12Matthew Stockman/Getty Images
After graduating from Georgia this spring, the North Carolina native has already made a splash, beating five straight opponents in third-set tiebreakers to reach the final of the Legg Mason event in Washington, D.C. At 6-foot-9, he has an elephant gun for a serve.
8 of 12David E. Klutho/SI
This quirky American veteran (and successful author of a locker-room exposé) isn't a threat to win, but he could give the right opponent trouble.
9 of 12Jamie Squire/Getty Images
The Georgia native has had a rough go of it in '07, but he did reach the semifinals in '05. New coach Jose Higueras has already paid dividends.
10 of 12Al Bello/Getty Images
He's still only 18, and the '07 Wimbledon junior champ is starting to live up the hype. On the basis of his whimsical, lefty game alone, he's worth watching.
11 of 12Al Bello/Getty Images
This industrious veteran is enjoying a nice late-career resurgence. She has never gone further than the third round of the U.S. Open, but bagged a couple of titles in the past few years and a demolition of Justine Henin in last spring's Nasdaq-100 in Miami.
12 of 12Lisa Blumenfeld/Getty Images
Bob & Mike Bryan
Who needs singles play? The Bryans are probably the best American hope for a crown in Queens. The Los Angeles-area twins are the top seed in the men's doubles draw and already have a U.S. Open title under their belts from '05 -- they've also completed a career Grand Slam with four other major titles.
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