Caleb Farley hoped to leave his history of health issues behind him in college. That did not work.

The Tennessee Titans’ first-round pick in the 2021 NFL Draft was ruled out Friday for Sunday’s Week 2 contest at Seattle. Farley, a cornerback out of Virginia Tech, sat out the last two days of practice with a shoulder issue after having been a full participant in Wednesday’s workout.

The issue arose after he played sparingly (eight snaps on defense, 10 on special teams) in the season-opener against Arizona.

Farley is the only Tennessee player to be ruled out ahead of Sunday’s game against the Seahawks in Seattle. Three others were listed as questionable, all starters – outside linebacker Bud Dupree, inside linebacker Jayon Brown and tight end Anthony Firkser.

Farley was available to the Titans with the No. 22 overall pick largely because of his injury history in college. A herniated disc sustained while lifting weights in 2019 led to two back surgeries in a little more than a year, the second just months before the draft. A knee injury during preseason camp turned his freshman season (2017) into a redshirt year. And he sat out all of 2020 due to COVID concerns and other factors.

All told, he played just 24 games in his college career.

One game into his NFL career, he already is hurting.

The complete Titans-Seahawks injury report for Friday:

TENNESSEE

Did not practice: ILB Jayon Brown (hamstring), CB Caleb Farley (shoulder) and TE Anthony Firkser (knee). Limited participation: OLB Bud Dupree (knee). Full participation: WR A.J. Brown (knee), ILB Rashaan Evans (hamstring), CB Chris Jackson (hamstring), OLB Harold Landry (groin), ILB David Long (hamstring), WR Josh Reynolds (foot) and OLB Derick Roberson (groin).

Sunday status: Out – Farley; Questionable – Jayon Brown, Dupree and Firkser. 

SEATTLE

Did not practice: T Duane Brown (not injury related), WR D'Wayne Eskridge (concussion), G Damien Lewis (groin) and RB Rashaad Penny (calf). Limited participation: DT Bryan Mone (elbow) and CB D.J. Reed (calf). Full participation: DT Poona Ford (shoulder), WR Penny Hart (concussion) and T Jamarco Jones (knee).

Sunday status: Out – none; Doubtful – Eskridge and Penny.Questionable – Lewis, Mone and Reed.