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#20 Duke vs. #18 Louisville Prediction, Picks & Odds: Saturday, 10/28

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This matchup between Duke and Louisville is one of the best games on the college football schedule this week. It’s just one of two games on the slate between AP Top 25 teams and both are still in the mix to reach the ACC Championship game. In this article, we will have a preview of the matchup, including a Duke vs. Louisville prediction that can be used to earn up to $1,500 in bonus bets from BetMGM Sportsbook.

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DUKE VS. LOUISVILLE PREDICTION: UNDER 46 (-110) at BetMGM Sportsbook

Click here to use our Duke vs. Louisville prediction to secure up to $1,500 in first-bet insurance from BetMGM Sportsbook.

Duke Blue Devils vs. Louisville Cardinals Prediction for Saturday's ACC Matchup, 10/28

Both teams in this matchup are coming off of losses, due to dreadful second-half performances. Both teams led at halftime but neither scored a single point in the second half. Duke’s performance was somewhat understandable, as the loss came against #4 Florida State. Louisville’s loss was shocking, as the Cardinals lost by 17 against Pittsburgh, who were 1-4 entering last week.

After careful evaluation of the Duke vs. Louisville odds available at BetMGM, our experts are recommending a bet on Under 46 (-110 at BetMGM Sportsbook). You can follow our Duke vs. Louisville prediction at BetMGM by clicking here. Our link automatically enters you into the BetMGM promotion that provides up to $1,500 in first-bet protection.

Duke vs. Louisville Best Bets & Expert Picks

Our experts see this game being low low-scoring based on the strength of each team’s defense. Duke is among the best defenses in the country, as the Blue Devils rank 19th nationally in EPA per play. They’re particularly strong in pass defense, where they rank fifth in opponent yards per pass attempt. This will provide a challenge to a Louisville offense led by Quarterback Jack Plummer. Plummer has thrown for over nine yards per attempt and has 13 touchdowns on the year.

On the other side of the ball, Duke’s offense is a run-heavy attack. Per TeamRankings, Duke ranks 24th in run play percentage at just over 56 percent of their offensive plays. In this matchup, they’ll be up against one of, if not the best run defenses in the country. Louisville ranks first in EPA per play against the run and tied for 14th in yards per carry allowed.

We’ve also seen both offenses struggle for large periods of the game, as evidenced last week when the teams combined for zero points against their respective opponents.

Our Duke vs. Louisville prediction includes a recommended bet on Under 46 (-110 at BetMGM Sportsbook). When you use our link to join BetMGM, you can secure up to $1,500 in bonus bets if your first bet doesn’t win.

How to be Granted Your Wager Back up to $1,500 in Case Under 46 Loses Thanks to BetMGM Sportsbook

As long as you join BetMGM using one of the links in the article, your first bet with BetMGM already has first-bet insurance applied. To complete the registration process, use the steps below.

  1. Click here to sign up for BetMGM Sportsbook
  2. Deposit $10+ into your account
  3. Place a $10-$1,500 bet using any Duke vs. Louisville odds, or any other college football market
  4. If your first bet doesn’t win, you will receive bonus bets back equal to your losing wager

Remember, no promo code is required to join, but you must use our unique link in order to be eligible.

Duke vs. Louisville Odds & Betting Lines via BetMGM for Saturday, October 28th, 2023

Our experts’ Duke vs. Louisville prediction includes a bet on Under 46 (-110 at BetMGM). However, BetMGM has other Duke vs. Louisville odds available for betting as well. Let’s take a look at the odds for the game, provided by BetMGM Sportsbook.

Duke Blue Devils vs. Louisville Cardinals - Saturday, October 28th - 3:30 PM ET

  • Point Spread: Duke +4 (-110) vs. Louisville -4 (-110)
  • Moneyline: Duke +160 vs. Louisville -190
  • Game Total (Over/Under): Over 46 (-110) vs. Under 46

In addition to the odds above, you can also use our Duke vs. Louisville prediction to bet on player props at ParlayPlay. When you use our link to join ParlayPlay, you are eligible to receive a deposit match of up to $100. No promo code is required to secure the deposit bonus, but you must click here to sign up.

Duke vs. Louisville Injury Report

The biggest injury to monitor before placing a bet on any Duke vs. Louisville odds is the status of Duke Quarterback Riley Leonard. Leonard returned from injury for the Florida State game before ultimately reinjuring his ankle. At the time of writing, he is questionable for the game.

On the Louisville side, Running Back Jawhar Jordan is questionable for this game with a hamstring injury. If either Jordan or Leonard is out, our experts’ Duke vs. Louisville prediction of Under 46 would have a good chance of winning.

Click here to join BetMGM and use our Duke vs. Louisville prediction to secure up to $1,500 in first-bet insurance.

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