NFL Week 16 Straight Up Picks + Odds & Spreads for All 16 Games
The NFL regular season is nearly over, and another 16 games are on the schedule this week, starting tonight with Thursday Night Football.
This article provides you with our NFL Week 16 picks straight up for every game this weekend. We also include all of the NFL spreads for Week 16, plus we outline the current DraftKings welcome bonus that all new customers can take advantage of with a qualifying bet on any of the NFL spreads for Week 16 or one of our NFL picks straight up.
If you prefer to get started without the details, sign up for a new DraftKings account with our link and by using our link, no promo code will be required.
If you’re in Vermont and ready to take advantage of the launch of sports betting, make sure to check out DraftKings' welcome offer to register and earn $200 in bonus bets.
NFL WEEK 16 PREDICTIONS: Colts ML (-105 at DraftKings Sportsbook)
Click here to create a new DraftKings account, and you will be eligible to receive $150 in bonus bets and a No Sweat SGP token every day with a $5 opening wager on one of our NFL picks straight up.
NFL Straight-Up Picks & Predictions for All 16 Games in Week 16
Provided below are our NFL Week 16 picks straight up for every game this week:
New Orleans Saints vs. Los Angeles Rams Pick
Starting with the game tonight, the 7-7 Saints will take on the 7-7 Rams. The Saints are coming off back-to-back wins and now find themselves in the hunt for the NFC South division title. They have allowed just six points in each of their last two games. Therefore, backing the Saints to win will be our prediction.
Saints Money Line +170
Cincinnati Bengals vs. Pittsburgh Steelers Pick
While the Bengals have had their ups and downs this season, the Steelers have been much worse. Their record is 7-7, but Pittsburgh’s offense has been lifeless, so because of that, backing the Bengals to win will be our best bet.
Bengals Money Line -135
Buffalo Bills vs. Los Angeles Chargers Pick
The Bills just got a huge win over the Cowboys and now face a terrible Chargers team that allowed 63 points to the Raiders. Backing the Bills to win will be our play.
Bills Money Line -650
Indianapolis Colts vs. Atlanta Falcons Pick
The Falcons continue to lack any real offense with Arthur Smith as the head coach. If a loss to the Panthers was not enough to get Smith fired, a loss this week to the Colts might be. Look for the Colts to roll in Atlanta.
Cleveland Browns vs. Houston Texans Pick
Joe Flacco has rallied the Browns to back-to-back wins, while the Texans might be without CJ Stroud. Without Stroud, the Texans are not a team that should be trusted. Therefore, backing the Browns is one of our NFL picks straight up.
Browns Money Line +120
Washington Commanders vs. New York Jets Pick
Both the Commanders and Jets have been terrible this season, but Washington has a more reliable quarterback with Sam Howell, so backing them to win is another one of our NFL picks straight up.
Commanders Money Line: +130
Seattle Seahawks vs. Tennessee Titans Pick
The Seahawks are coming off an impressive win over the Eagles, while the Titans are below average and do not have a consistent offense. For that reason, the Seahawks will be our pick.
Seahawks Money Line: -135
Green Bay Packers vs. Carolina Panthers Pick
The Panthers may have beaten the Falcons, but are still the worst team in the league. Meanwhile, the Packers are inconsistent but have more upside with Jordan Love, making them our pick to win.
Packers Money Line: -225
Detroit Lions vs. Minnesota Vikings Pick
The Lions are looking like a dangerous team, and with the chance to lock up the NFC North, backing them to win will be our prediction.
Lions Money Line: -162
Jacksonville Jaguars vs. Tampa Bay Buccaneers Pick
The Jaguars looked lifeless against the Ravens, but are still a better team compared to the Buccaneers. With Trevor Lawrence the better quarterback, backing the Jaguars to win will be one of our NFL picks straight up.
Jaguars Money Line: -110
Arizona Cardinals vs. Chicago Bears Pick
Two of the worst teams in the league will go head-to-head here, but with Arizona having already been eliminated and Chicago still with very slim playoff hopes, backing the Bears to win will be our bet.
Bears Money Line: -218
Dallas Cowboys vs. Miami Dolphins Pick
The Cowboys fell flat on their face against the Bills, and facing the Dolphins’ offense is only going to be a tougher task. Miami is rolling right now and looks like a Super Bowl contender, so backing them to win will be one of our NFL picks straight up.
Dolphins Money Line: -122
New England Patriots vs. Denver Broncos Pick
Both teams have had trouble this season, but New England is simply terrible, while the Broncos still have a chance to make the playoffs. Because the Broncos have something to play for, backing them to win is our play.
Broncos Money Line: -285
Las Vegas Raiders vs. Kansas City Chiefs Pick
The first Christmas Day game will see the Raiders take on the Chiefs. While the Chiefs have had some poor performances this season, they are simply a much better team than the Raiders and should have no problem beating them at home.
Chiefs Money Line: -500
New York Giants vs. Philadelphia Eagles Pick
The Eagles continue to play mediocre football, but at home and on Christmas against the Giants is a great spot for them to bounce back. Back the Eagles to win.
Eagles Money Line: -600
Baltimore Ravens vs. San Francisco 49ers Pick
The best game of the week will see the Ravens and 49ers play on Christmas. As good as the Ravens have been, the 49ers have been crushing teams almost every week. With Christian McCaffrey a potential MVP candidate, backing the 49ers to win will be our play.
49ers Money Line: -238
By simply using any of our NFL picks straight up, you will be eligible for $150 in bonus bets and a No Sweat SGP token everyday.
Bet on Our Straight Up NFL Picks With DraftKings Sportsbook & Get $150+ in Betting Bonuses
This DraftKings welcome offer instantly gives new customers $150 in bonus bets. All you need to do is deposit at least $5 and make a minimum $5 qualifying bet on one of our NFL picks straight up or any of the NFL spreads for Week 16. Once you place your first bet, $150 in bonus bets will be credited to your account.
On top of guaranteed bonus bets, you also receive a No Sweat SGP token that can be used once every day. For each SGP you make that loses, a bonus bet equal to the amount you bet will be refunded to your account.
Below are the terms and conditions to be aware of before you unlock the current DraftKings new-user promo:
- New customers only
- Age requirement: 21+
- Eligible states: AZ, CO, CT, IA, IL, IN, KS, LA, MA, MD, MI, NJ, NY, OH, PA, TN, VA, WV, or WY
- Minimum deposit: $5
- Bet at least $5 on any of the NFL spreads for Week 16 or our NFL picks straight up
No Sweat SGP Portion
- No minimum odds required
- SGP must be at least three legs
- Cash funds only
- SGP token must be applied before placing your bet
- Bonus bets are paid as one bet on losing bets only
New customers can unlock this offer by opening a new DraftKings account via our link without needing a promo code.
Odds & Spreads for All 16 Games This Week
All the NFL spreads this week are listed below, and note all of the listed NFL spreads for Week 16 are taken from DraftKings Sportsbook:
Thursday, December 21st
- New Orleans Saints +4 (-110) vs. Los Angeles Rams -4 (-110)
Saturday, December 23rd
- Cincinnati Bengals -2.5 (-115) vs. Pittsburgh Steelers +2.5 (-110)
- Buffalo Bills -10.5 (-110) vs. Los Angeles Chargers +10.5 (-110)
Sunday, December 24th
- Indianapolis Colts -2.5 (-105) vs. Atlanta Falcons +2.5 (-115)
- Cleveland Browns +2.5 (-108) vs. Houston Texans -2.5 (-112)
- Washington Commanders +3 (-115) vs. New York Jets -3 (-105)
- Seattle Seahawks -2.5 (-110) vs. Tennessee Titans +2.5 (-110)
- Green Bay Packers -5 (-110) vs. Carolina Panthers +5 (-110)
- Detroit Lions -3 (-110) vs. Minnesota Vikings +3 (-110)
- Jacksonville Jaguars -1 (-105) vs. Tampa Bay Buccaneers +1 (-115)
- Arizona Cardinals +4 (-105) vs. Chicago Bears -4 (-110)
- Dallas Cowboys +1.5 (-110) vs. Miami Dolphins -1.5 (-110)
- New England Patriots +6.5 (-110) vs. Denver Broncos -6.5 (-110)
Monday, December 25th
- Las Vegas Raiders +10 (-110) vs. Kansas City Chiefs -10 (-110)
- New York Giants +10.5 (-110) vs. Philadelphia Eagles -10.5 (-110)
- Baltimore Ravens +5.5 (-110) vs. San Francisco 49ers -5.5 (-110)
Any of the NFL spreads this week can be used as your qualifying bet for the DraftKings promotion offering $150 in bonus bets and a daily No Sweat SGP token.
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