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NFL Week 3 Picks Against the Spread & Predictions for All 16 Games

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The third week of the 2023-24 NFL season is already upon us as it seems like just yesterday we were all watching the Lions vs. Chiefs open up the season on TNF. We’re now two games into the campaign though, with spectators and teams starting to get a general idea of what kind of season each franchise is about to endure. With that being said, we’ve rounded up our NFL Week 3 picks against the spread for every single one of this week’s contests below.

It’s important to note that we grabbed all the betting odds and lines that you see in this article from DraftKings Sportsbook. They currently have a $350 new-user promo on offer for anyone who signs up today.

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NFL Week 3 Picks Against The Spread at DraftKings Sportsbook

As we just mentioned, we’ve made NFL Week 3 picks against the spread for all 16 games taking place this week. You can check out our predictions below, with the betting lines and odds courtesy of DraftKings Sportsbook:

Thursday, September 21:

  • New York Giants +10.5 (-110) vs. San Francisco 49ers -10.5 (-110)

Sunday, September 24:

  • Atlanta Falcons +3.5 (-110) vs. Detroit Lions -3.5 (-110)
  • Los Angeles Chargers -1 (-110) vs. Minnesota Vikings +1 (-110)
  • New Orleans Saints +2 (-110) vs. Green Bay Packers -2 (-110)
  • Houston Texans +8.5 (-108) vs. Jacksonville Jaguars -8.5 (-112)
  • Denver Broncos +6.5 (-108) vs. Miami Dolphins -6.5 (-112)
  • Tennessee Titans +3.5 (-112) vs. Cleveland Browns -3.5 (-108)
  • Buffalo Bills -6.5 (-115) vs. Washington Commanders +6.5 (-105)
  • Indianapolis Colts +7.5 (-110) vs. Baltimore Ravens -7.5 (-110)
  • New England Patriots -3 (-105) vs. New York Jets +3 (-115)
  • Carolina Panthers +5.5 (-105) vs. Seattle Seahawks -5.5 (-115)
  • Chicago Bears +13 (-110) vs. Kansas City Chiefs -13 (-110)
  • Dallas Cowboys -12 (-110) vs. Arizona Cardinals +12 (-110)
  • Pittsburgh Steelers -1 (-108) vs. Las Vegas Raiders +1 (-112)

Monday, September 25:

  • Philadelphia Eagles -5.5 (-110) vs. Tampa Bay Buccaneers +5.5 (-110)
  • Los Angeles Rams +2 (-110) vs. Cincinnati Bengals -2 (-110)

NFL Week 3 Predictions Featuring Titans vs. Browns

Regarding our favorite NFL Week 3 predictions, the best bet in our eyes has to target the Cleveland Browns. They welcome in the Tennessee Titans on Sunday in a battle between two 1-1 teams. However, we believe the game being played in Cleveland will make all the difference.

The Titans and Browns are both winless on the road to start this season and undefeated at home. We like that trend to continue in this one, as Teneessee’s pedestrian offense shouldn’t be able to move the ball a whole bunch against a stingy defensive unit for Cleveland. Additionally, the Browns and QB Deshaun Watson should have what it takes to score against the Titans defense, even without star RB Nick Chubb.

The only real advantage Tennessee has in this game from a positional standpoint is running back, and that’s only because Chubb is now out. Even with that statement ringing true, Derrick Henry hasn’t popped off yet this season and his best days may be behind him. Taking everything into account, one of our NFL Week 3 best bets sides with the Browns -3.5 (-108 at DraftKings).

How to Bet on Our Expert Picks at DraftKings Sportsbook & Get up to $350 in Bonuses Guaranteed

We briefly touched on it previously, but the latest DraftKings Sportsbook sign-up bonus is certainly one of the best betting promotions on the market. It has a total value of $350, and we made a quick guide instructing on how to claim it here:

  1. Use this link to register at DraftKings Sportsbook
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  3. Place a $5+ wager on our NFL Week 3 picks against the spread

No matter the result of your qualifying wager, you’ll be granted $200 in bonus bets in addition to three separate $50 No Sweat Bet tokens. You can also place your qualifying wager on any available market, not just our NFL Week 3 predictions or picks against the spread. With no promo code required to be eligible, this promo couldn’t be easier to claim. Simply register here for a new account at DraftKings.

NFL Week 3 Schedule & Betting Lines Provided by DraftKings Sportsbook, September 2023

In this section, we laid out this week’s money line odds at DraftKings Sportsbook for each matchup, as well as the time that each contest is taking place. Between our NFL Week 3 picks against the spread and now this list here, we should have you perfectly geared up to enjoy a phenomenal week of NFL action.

Thursday, September 21:

  • New York Giants (+410) vs. San Francisco 49ers (-550) - 8:15 PM ET

Sunday, September 24:

  • Atlanta Falcons (+150) vs. Detroit Lions (-180) - 1:00 PM ET
  • Los Angeles Chargers (-115) vs. Minnesota Vikings (-105) - 1:00 PM ET
  • New Orleans Saints (+105) vs. Green Bay Packers (-125) - 1:00 PM ET
  • Houston Texans (+320) vs. Jacksonville Jaguars (-410) - 1:00 PM ET
  • Denver Broncos (+230) vs. Miami Dolphins (-285) - 1:00 PM ET
  • Tennessee Titans (+150) vs. Cleveland Browns (-180) - 1:00 PM ET
  • Buffalo Bills (-278) vs. Washington Commanders (+225) - 1:00 PM ET
  • Indianapolis Colts (+310) vs. Baltimore Ravens (-395) - 1:00 PM ET
  • New England Patriots (-142) vs. New York Jets (+120) - 1:00 PM ET
  • Carolina Panthers (+200) vs. Seattle Seahawks (-245) - 4:05 PM ET
  • Chicago Bears (+525) vs. Kansas City Chiefs (-750) - 4:25 PM ET
  • Dallas Cowboys (-675) vs. Arizona Cardinals (+490) - 4:25 PM ET
  • Pittsburgh Steelers (-115) vs. Las Vegas Raiders (-105) - 8:20 PM ET

Monday, September 25:

  • Philadelphia Eagles (-218) vs. Tampa Bay Buccaneers (+180) - 715 PM ET
  • Los Angeles Rams (+105) vs. Cincinnati Bengals (-125) - 8:15 PM ET

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