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#12 Duke vs. Louisville Prediction, Picks & Betting Odds for Today, 1/23

The Duke Blue Devils and the Louisville Cardinals will face off tonight in the KFC Yum! Center for an ACC matchup. This game will tip off at 7:00 PM Eastern Standard Time and can be seen on the ACC Network. Duke will be on the road for game one of the season series before going back home for game two of the series on February 28th. It will be a loaded slate of ACC games tonight with three other games in action, but the Blue Devils are the only ranked team in the conference playing. We have shared our expert Duke vs. Louisville picks below.

Duke enters tonight’s game with an impressive 13-4 record and holds the #12 overall ranking, according to yesterday’s AP Top 25 Poll. They are coming off a shocking home loss to Pittsburgh and should be hungry to get back on track here. Louisville holds a 6-12 record this season and have been one of the worst teams in the country. 

A win here would be one of the biggest upset wins of the season and would completely change the rest of their season. This is still a battle of two historic programs, so we have shared our expert Duke vs. Louisville prediction with odds provided by FanDuel Sportsbook.

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Duke vs. Louisville Prediction: Duke -14.5 (-110 at FanDuel Sportsbook)

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Duke vs. Louisville Prediction for Today’s College Basketball Game, 1/23

The Duke Blue Devils will travel to Kentucky tonight to play an ACC game against the Louisville Cardinals. Duke will look to bounce back from their upset loss to Pittsburgh on Saturday and get back on track with a win here. They are currently three games back from North Carolina in the ACC standings, so wins are needed to get them back in the hunt for the league title. Louisville is just 1-6 in the conference so far this season, so we expect Duke to take care of business on the road here. Our expert Duke vs. Louisville spread pick is Duke -14.

Duke -14.5 offered at FanDuel Sportsbook is our expert Duke vs. Louisville prediction because Louisville has been one of the worst teams in the entire country this year. The Cardinals are struggling heavily in head coach Kenny Payne’s second season and the end of his tenure seems near. They are just 6-12 on the year and have losses to bad teams such as DePaul, Arkansas State and Chattanooga. We can’t see them keeping it close against a Duke team that is much more talented and better coached, so Duke -14 is our best bet.

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Duke vs. Louisville Picks & Best Bets Featuring Duke -14.5

Duke -14 is our expert Duke vs. Louisville prediction because the Blue Devils should be able to dominate both sides of the ball. Louisville’s defense has been one of the worst in the country and should have trouble stopping Duke’s offense. According to KenPom, Louisville’s defense is ranked #244 in adjusted efficiency, #298 in effective field goal percentage, #252 in three-point percentage and #292 in two-point percentage.

Duke’s offense is ranked in the top 50 in all of those categories and should have no problems putting up points tonight. Use our Duke vs. Louisville prediction and head to FanDuel Sportsbook to place your wagers.

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Duke vs. Louisville Betting Odds, Lines & Spreads at FanDuel Sportsbook

We have highlighted the Duke vs. Louisville odds at FanDuel Sportsbook below:

  • Spread: Duke -14.5 (-102) vs. Louisville +14.5 (-120)
  • Money Line: Duke (-1300) vs. Louisville (+760)
  • Total: Over 150.5 (-108) / Under 150.5 (-112)

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Probable Lineups for Duke vs. Louisville

The probable starting lineups for both teams are highlighted below:

Duke:

G Jaylen Blakes

G Jared McCain

G Caleb Foster

G Tyrese Proctor

C Kyle Filipowski

Louisville:

G Tre White

G Skyy Clark

G Zan Payne

G Mike James

F Brandon Huntley-Hatfield

Check out the updated Duke vs. Louisville odds and place a wager using our expert Duke vs. Louisville prediction after you click here to sign up with FanDuel Sportsbook

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