Skip to main content

Louisville vs. #10 Duke Prediction, Picks & Betting Odds for Today, 2/28

With just a few games left in the college basketball regular season, teams are looking to make their final push toward March Madness. It’s no surprise that Duke will be in the NCAA Tournament, but the Blue Devils are still playing to earn the best possible seed. 

In this article, we preview tonight’s game against Louisville, including an official expert Louisville vs. Duke prediction. You can use our Louisville vs. Duke picks to unlock a No Sweat First Bet worth up to $1,000 at DraftKings Sportsbook. Keep reading for the details, or click here to claim the offer now. No promo code is required when you join through one of our links.

If you’re looking forward to betting on the NCAA Tournament this spring, don’t forget to review the best March Madness betting sites to unlock $3,000+ in bonuses as a new user.

LOUISVILLE VS. DUKE PREDICTION: DUKE -20 (-110 at DraftKings Sportsbook)

Click here become a NEW member of DraftKings☀️ and use our Louisville vs. Duke prediction to unlock a $1,000 No Sweat First Bet, ensuring you get your losses back in a bonus bet.

Louisville vs. Duke Prediction for Today's College Basketball Game

As mentioned in the intro, Duke is headed to the NCAA Tournament this year, it’s just a matter of what seed they will get. As it stands now, Bracket Matrix has Duke as a #3 seed, but that could improve with a strong finish to the regular season. The Blue Devils definitely cannot slip up against lowly Louisville, which enters this game with a record of 8-19.

Duke won at Louisville earlier this year by a score of 83-69 and will look to repeat that comfortable result tonight. Louisville has lost three games in a row by double-digits and could be in trouble against a Duke team coming off of a loss to Wake Forest.

We have our official Louisville vs. Duke prediction in the next section, but you can 👉🏼 click this link to activate your account at DraftKings Sportsbook and claim your No Sweat First Bet.

Louisville vs. Duke Picks & Best Bets Featuring Duke -20

Based on the strength of each team in this matchup, it seems like it is a foregone conclusion that Duke will win this game. However, that’s why sports betting is enjoyable as margin of victory matters. Based on the matchup, our expert Louisville vs. Duke picks include a best bet of Duke -20 (-110 at DraftKings Sportsbook). 🔒

The big question heading into this game is the status of Duke’s Kyle Filipowski. Filipowski was injured after colliding with a fan following a court storming at Wake Forest. At the time of writing, his status for this game is unknown, but it seems like a wise decision to rest him if he is not 100 percent. Duke is a big favorite against Louisville and having Filipowski at full strength for the postseason is crucial.

Even if Filipowski does not play, Duke still has an overwhelming advantage over Louisville. Filipowski is the team’s leading scorer, but there are four other Blue Devils that average double-figures in points. Duke could have a big day from beyond the arc, as they lead the ACC in three-point percentage. Louisville is the worst defense in the conference and has allowed their opponents to connect on almost 40 percent of their three-point attempts.

With or without Filipowski, our experts’ Louisville vs. Duke prediction includes a recommended bet on Duke -20 (-110 at DraftKings Sportsbook). 🔒 Click our pick to either follow our prediction or make Louisville vs. Duke picks of your own at DraftKings Sportsbook and activate the $1,000 new-user promo.

How to Tail Our UL vs. Duke Pick to Unlock $1,000 in Betting Bonuses

No matter if you’d like to follow our Louisville vs. Duke prediction or make picks of your own, be sure to sign up for DraftKings Sportsbook. Follow the steps below to claim your No Sweat First Bet worth up to $1,000.

  1. ➡️ Click here to join DraftKings Sportsbook ⬅️
  2. Make a deposit of at least $5
  3. Bet up to $1,000 on any Louisville vs. Duke odds available at DraftKings
  4. If your first bet doesn’t win, you will receive a bonus bet equal to your losing bet.

Not only does the DraftKings new-user promo give you the No Sweat First Bet, but it provides daily Same Game Parlay insurance as well. Build an SGP with all legs having odds of -300 or longer and receive up to $100 in bonus bets if one leg loses. Remember, you don’t need a promo code to unlock the offer, but you join DraftKings through one of our links.

Louisville vs. Duke Betting Odds, Lines & Spreads at DraftKings Sportsbook

Our best bet is on the Louisville vs. Duke spread, but you could also bet on tonight’s game in another market. Listed below are the available Louisville vs. Duke odds at DraftKings Sportsbook.

Louisville Cardinals vs. Duke Blue Devils - Wednesday, February 28th - 7:00 PM ET

  • Point Spread: Louisville +20 (-110) vs. Duke -20 (-110)
  • Money Line: Louisville +1200 vs. Duke -2400
  • Game Total (Over/Under): Over 151.5 (-112) vs. Under 151.5 (-108)

Click here to create your DraftKings Sportsbook account and place your first bet on any of the above Louisville vs. Duke odds.

Probable Lineups for Louisville vs. Duke Today, 2/28

Before making your Louisville vs. Duke picks, make sure to check the lineups for the game. The probable lineups for each team are listed below but could change given the status of Duke’s Kyle Filipowski.

Louisville Cardinals

  • Mike James
  • Skyy Clark
  • Tre White
  • Brandon Huntley-Hatfield
  • Kaleb Glenn

Duke Blue Devils

  • Jeremy Roach
  • Jared McCain
  • Caleb Foster
  • Mark Mitchell
  • Kyle Filipowksi - Questionable

Use our link and Louisville vs. Duke prediction to secure your No Sweat First Bet at DraftKings Sportsbook.

Kyle Filipowski Injury Update

At the time of writing, Duke’s Kyle Filipowski is questionable with a knee injury. Given the large Louisville vs. Duke spread, it’s very reasonable to assume that Duke will rest him in tonight’s game.

Make your Louisville vs. Duke picks for tonight’s matchup by clicking here to join DraftKings.

Enjoyed this article? Further enhance your betting experience with our guides, handpicked for you:

If you or a loved one has questions or needs to talk to a professional about gambling, call 1-800-GAMBLER or visit 1800gambler.net for more information.

The Arena Media Brands, LLC and its partners may receive compensation for links to products and services on this website. The Arena Media Brands editorial team is not involved in the creation of this content.