#10 Notre Dame vs. #25 Louisville Prediction, Picks & Odds: 10/7 on ABC
First-year Louisville coach, and former Cardinals standout quarterback Jeff Brohm has wasted no time making his mark at his alma mater. Louisville has jumped out to a 5-0 start behind transfer quarterback Jack Plummer, who despite throwing six interceptions, has completed 65% of his passes for 1,406 yards and 11 touchdowns. Jamari Thrash has 22 catches for 444 yards and five touchdowns and Jawhar Jordan has rushed for 510 yards and six touchdowns.
Ashton Gillotte’s five sacks pace a defense that has held opponents to 14 points or less three times in five games while posting one shutout.
They’ll need that balance and defensive pressure as No. 10 Notre Dame comes to town Saturday night coming off two last-second contests, one a heartbreaking loss to Ohio State, followed by last weekend’s escape win at Duke. This is the third straight week the Fighting Irish have faced a ranked opponent.
What will happen in this pseudo-ACC matchup? Let’s dive into our Notre Dame vs. Louisville prediction available at DraftKings Sportsbook. If you’re in Kentucky and ready to take advantage of the launch of sports betting, make sure to check out DraftKings' welcome offer to register and earn $200 in bonus bets.
NOTRE DAME VS. LOUISVILLE PREDICTION: UNDER 54 POINTS [-110 ODDS at DraftKings Sportsbook]
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Notre Dame Fighting Irish vs. Louisville Cardinals Prediction: CFB This Week
Look, both teams have explosive capabilities on offense. But, in last week’s games against ranked opponents, Notre Dame’s total points were 31 and 35, respectively. Transfer quarterback Sam Hartman has been amazing for the Fighting Irish, throwing for 1,458 yards and 14 touchdowns with no interceptions.
Audric Estime has also been great rushing for nearly 700 yards and seven touchdowns already, but the vaunted Irish offensive line has struggled lately. With a number of false starts at Duke and the wide receiver corps has been decimated without Jayden Thomas, Jaden Greathouse and Deion Colzie.
These 21-14 games just seem to be in the Irish’s wheelhouse right now. And Louisville is coming off a 13-10 squeaker over N.C. State. Although both team’s offenses will be looking to break out, our experts have more confidence in the defensive side of the ball in this contest.
The bet here is that this game will be another tightrope late into the fourth quarter. There should be more points than what both teams scored last week, but the official Notre Dame vs. Louisville prediction is for the total points scored to go under the 54 listed at DraftKings.
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Notre Dame vs. Louisville Picks & CFB Best Bets for Saturday Including Under 54 Points
The DraftKings Sportsbook spread for this game has Notre Dame giving 6.5 points to Louisville. Our experts cannot confidently say that either side will come out with a win, but their prediction is that Louisville will cover that 6.5-point spread. And, again, they believe that the total points scored in the game will go under 54.
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You can bet on under 54 points to be scored in Notre Dame vs. Louisville over at DraftKings Sportsbook, which has a great promotion for you to take advantage of right now. When you sign up for a DraftKings account using this link, and then wager $5 on your first bet, you automatically get $200 in bonus bets from DraftKings, no matter if that initial wager wins or loses. You’ll also be able to opt in for a No Sweat same game parlay token every day this season.
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Latest Notre Dame vs. Louisville Betting Lines, Odds & Spread for 10/7 Courtesy of DraftKings
Again, Notre Dame is currently listed as a 6.5-point favorite at -110 odds. That means the bet would be a winner if Notre Dame wins by 7 points or more. If the Fighting Irish can deliver on that bet, a $110 wager would return $100 in profit.
Louisville is a 6.5-point underdog, also at -110 odds, meaning they must win or lose by 6 points or less for the bet to be successful. A $110 bet would deliver $100 in winnings if Louisville covers the spread.
If you want to focus on just the money line, Notre Dame is listed as -265 to win, meaning you would need to bet $265 on them to simply win the game to get $100. Louisville is listed as +215 to win, so if you wager on their money line and they pull off the upset, you get $215 for every $100 you bet.
And, as highlighted above, the game total for Notre Dame vs. Louisville is set at 54, with -110 odds on both the over and the under. Whichever side you want to back, you’ll win $10 for every $11 staked if your bet is successful. To bet on any of these markets now, click here to join DraftKings Sportsbook, and you’ll receive $200 worth of free bets just for placing a $5 bet on any of these Notre Dame vs. Louisville odds.
Louisville Football Ranked for the First Time This Season
After defeating N.C. State last week, the Cardinals entered both the AP Top 25 and coaches poll for the first time this season. Louisville is off to its best start in a decade. That ranking and perfect record will be put to the test Saturday night against Notre Dame.
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