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Mar 19, 2026; Buffalo, NY, USA; Louisville Cardinals center Aly Khalifa (15) looks to pass as South Florida Bulls forward Daimion Collins (6) defends during the first half during a first round game of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Gregory Fisher-Imagn Images

The Cardinals and Spartans do battle for the right to head to the Sweet 16.

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The Cardinals and Spartans do battle for the right to head to the Sweet 16.

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Mar 18, 2026; Buffalo, NY, USA; Louisville Cardinals Guard Mikel Brown Jr. (0) shoots the ball during a practice session ahead of the first round of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Gregory Fisher-Imagn Images

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The Cardinals take on the Spartans in the second round of the NCAA Tournament.

Mar 19, 2026; Buffalo, NY, USA; Louisville Cardinals guard Ryan Conwell (3) drives to the basket for a lay up during the first half against the South Florida Bulls during a first round game of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Mark Konezny-Imagn Images

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Here are the three main ways that the Cardinals can take down the Spartans and reach the Sweet 16.

Mar 18, 2026; Buffalo, NY, USA; Louisville Cardinals head coach Pat Kelsey answer questions during the press conference ahead of the first round of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Gregory Fisher-Imagn Images

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The Cardinals and Spartans will square off for the right to get to the second weekend of the NCAA Tournament.

U of L head coach Jeff Walz laughs as he teased ESPN reporter Alexa Philippou about picking the Cardinals to lose in the first round of the NCAA tournament during a press conference ahead of U of L s Elite 8 matchup with Iowa at the Climate Pledge Arena in Seattle, Wa. on Mar. 25, 2023. Philippou clarified that she thought it might be a possible upset win for Drake.

Cards Presser01 Sam

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The Cardinals and Catamounts square off in the first round of the Big Dance on Saturday.

Mar 1, 2026; Louisville, Kentucky, USA; Louisville Cardinals guard Skylar Jones (23) dribbles against Notre Dame Fighting Irish forward Malaya Cowles (5) during the first half at KFC Yum! Center. Mandatory Credit: Jamie Rhodes-Imagn Images

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The Arizona transfer had played in every game this season for the Cardinals.

Mar 19, 2026; Buffalo, NY, USA; Louisville Cardinals forward Sananda Fru (13) makes a slam dunk during the second half against the South Florida Bulls during a first round game of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Gregory Fisher-Imagn Images

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Take a look at how the Cardinals stack up against the Spartans for their NCAA Tournament matchup, and who the statistical models favor:

Mar 19, 2026; Buffalo, NY, USA; Louisville Cardinals guard Ryan Conwell (3) drives to the basket during the second half against the South Florida Bulls during a first round game of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Gregory Fisher-Imagn Images

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The Cardinals and Spartans meet once again in the Big Dance, this time with a trip to the Sweet 16 on the line.

Mar 19, 2026; Buffalo, NY, USA; Louisville Cardinals guard Adrian Wooley (14) dribbles and looks to pass as South Florida Bulls guard Joseph Pinion (5) defends during the first half during a first round game of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Mark Konezny-Imagn Images

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The Cardinals took down the Bulls to capture their first win in the NCAA Tournament since 2017.

Mar 19, 2026; Buffalo, NY, USA; Louisville Cardinals guard Isaac McKneely (10) reacts to a play during the second half against the South Florida Bulls during a first round game of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Mark Konezny-Imagn Images

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The highlights, photo gallery plus team & player notes from the Cardinals' win over the Bulls.

Mar 19, 2026; Buffalo, NY, USA; Louisville Cardinals head coach Pat Kelsey reacts during the first half against the South Florida Bulls during a first round game of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Gregory Fisher-Imagn Images

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Listen to what the head coach of the Cardinals and various payers said after their NCAA Tournament win over the Bulls:

Mar 19, 2026; Buffalo, NY, USA; Louisville Cardinals guard J'vonne Hadley (1) dribbles as South Florida Bulls guard Gavin Hightower (9) defends during the first half during a first round game of the men's 2026 NCAA Tournament at Keybank Center. Mandatory Credit: Mark Konezny-Imagn Images

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The Cardinals win their first game in the Big Dance in nearly a decade.

Mar 18, 2026; Buffalo, NY, USA; The court of the KeyBank Center arena ahead of the first round of the men's 2026 NCAA Tournament. Mandatory Credit: Mark Konezny-Imagn Images

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The Cardinals will get their run in the NCAA Tournament started with a matchup against the Bulls in Buffalo.

Mar 7, 2026; Duluth, GA, USA; Louisville Cardinals mascot Louie on the court against the North Carolina Tar Heels in the second quarter at Gas South Arena. Mandatory Credit: Brett Davis-Imagn Images

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The Cardinals tip off against the Bulls at 1:30 p.m. EST.

Mar 11, 2026; Charlotte, NC, USA; Louisville Cardinals forward Vangelis Zougris (53) reacts to a score during the second half against the Southern Methodist University Mustangs at Spectrum Center. Mandatory Credit: Jim Dedmon-Imagn Images

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The Cardinals head to Buffalo for a showdown against the Bulls to start their run in the Big Dance.

Louisville Cardinals guard Mikel Brown Jr. (0) was unfazed after he scored 45 points with 10-for-16 3-point shooting as the Cards roll past NC State 118-77 at the KFC Yum! Center in downtown Louisville February 9, 2026.

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The Cardinals take on the Bulls to kick off their run in the NCAA Tournament.

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The Cardinals and Bulls square off in the first round of the Big Dance on Thursday.

Feb 23, 2026; Chapel Hill, North Carolina, USA; Louisville Cardinals guard Mikel Brown Jr. (0) on the court in the second half at Dean E. Smith Center. Mandatory Credit: Bob Donnan-Imagn Images

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The star point guard has missed the last four games due to a lingering lower back injury.

Jan 17, 2026; Pittsburgh, Pennsylvania, USA; Louisville Cardinals guard J'vonne Hadley (1) brings the ball up court against the Pittsburgh Panthers during the first half at the Petersen Events Center. Mandatory Credit: Charles LeClaire-Imagn Images

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Take a look at how the Cardinals stack up against the Bulls for their NCAA Tournament matchup, and who the statistical models favor:

Mar 12, 2026; Charlotte, NC, USA; Louisville Cardinals guard Adrian Wooley (14) with the ball as Miami (FL) Hurricanes guard Dante Allen (35) defends in the first half at Spectrum Center. Mandatory Credit: Bob Donnan-Imagn Images

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Here are the three main ways that the Cardinals can take down the Bulls to start their run in the Big Dance.

Apr 8, 2013; Atlanta, GA, USA; Louisville Cardinals guard Peyton Siva (center) holds the trophy after Louisville won the championship game in the 2013 NCAA mens Final Four against the Michigan Wolverines at the Georgia Dome. Louisville Cardinals won 82-76. Mandatory Credit: Bob Donnan-Imagn Images

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The Cardinals have a rich history of success in the Big Dance.

Mar 12, 2026; Charlotte, NC, USA; Louisville Cardinals head coach Pat Kelsey reacts in the second half at Spectrum Center. Mandatory Credit: Bob Donnan-Imagn Images

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The Cardinals earned a No. 6 seed for the NCAA Tournament, and will face South Florida to get their run started.

Feb 23, 2026; Chapel Hill, North Carolina, USA; Louisville Cardinals guard Mikel Brown Jr. (0) with the ball in the first half at Dean E. Smith Center. Mandatory Credit: Bob Donnan-Imagn Images

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The star point guard for Louisville has missed the last four games due to his lingering lower back injury.

Mar 11, 2026; Charlotte, NC, USA; Louisville Cardinals mascot performs in the first half at Spectrum Center. Mandatory Credit: Bob Donnan-Imagn Images

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Follow along throughout the tournament as the Cardinals attempt to go on a run in the Big Dance.

Feb 21, 2026; Louisville, Kentucky, USA; Louisville Cardinals guard J'vonne Hadley (1) reacts during the first half against the Georgia Tech Yellow Jackets at KFC Yum! Center. Mandatory Credit: Jamie Rhodes-Imagn Images

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The Cardinals will get their run in the NCAA Tournament started with a matchup against the Bulls in Buffalo.