Louisville vs. Indiana Prediction, CFB Picks & Odds for Saturday, 9/16
The Louisville Cardinals football team has gotten off to a 2-0 start to their 2023-24 campaign after victories over Murray State just this past weekend and Georgia Tech in Week 1. Before heading back home to continue their ACC schedule, they have a matchup with a Big Ten opponent in the Indiana Hoosiers.
Below, you’ll find our experts’ best Louisville vs. Indiana prediction alongside a ‘Bet $5, get $200’ DraftKings Sportsbook sign-up bonus.
LOUISVILLE VS. INDIANA PREDICTION: Cardinals -9.5 (-110 at DraftKings Sportsbook)
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Louisville Cardinals vs. Indiana Hoosiers Prediction for CFB Week 3
Before diving into our Louisville vs. Indiana prediction, it’s worth noting that this weekend’s game is technically a neutral site matchup. Rather than being at Indiana University Memorial Stadium, it will be at Lucas Oil Stadium - home of the Indianapolis Colts.
Of course, that is still a more friendly location for the Hoosiers, but it is still worth noting. Regardless, we see the Cardinals as the clear favorites, and we’re expecting a win from their side as well. Given their experience at the most important position - quarterback - we’re predicting their offense to lead that charge.
Given they’ve averaged 47.5 points in their first two games, that shouldn’t come as much of a surprise. So, let’s get into the full analysis for our best Louisville vs. Indiana prediction.
Louisville vs. Indiana Picks & CFB Best Bets for Saturday Featuring the Cardinals -9.5
There’s no doubt that fans of the Hoosiers can argue that Louisville faced a far inferior opponent last weekend in Murray State. However, the Racers were coming off the high of a 41-10 win themselves, meaning their confidence was sky-high. The Cardinals also didn’t just squeak by - they shutout Murray State 56-0.
It also wasn’t as if Louisville scheduled that “cupcake” matchup as their season opener. They kicked off the year with a tough conference battle against Georgia Tech on the road, where QB Jack Plummer led the Cards to a win with three passing touchdowns. Indiana allowed the most passing yards per game in the Big Ten last season (274.2/game) and have only slightly improved this season.
The Cardinals will need to shore up their defense as well, but the Hoosiers simply don’t have the weapons they used to have when QB Michael Penix Jr. was around before transferring to Washington. The program hasn’t been the same since, so we’re confident making our best Louisville vs. Indiana prediction on the Cardinals -9.5 (-110 at DraftKings Sportsbook).
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Latest Louisville vs. Indiana Betting Lines, Odds & Spread for 9/16 at DraftKings
Based on the latest lines and odds at DraftKings Sportsbook that we’ve provided below, our Louisville vs. Indiana prediction on the Cardinals -9.5 has -110 odds, so an $11 wager profits $10 as long as they win by at least 10 points.
Point spread:
- Louisville Cardinals -9.5 (-110) vs. Indiana Hoosiers +9.5 (-110)
Money Line:
- Louisville Cardinals (-390) vs. Indiana Hoosiers (+300)
Total (over/under):
- Over 52 (-110) vs. Under 52 (-110)
DraftKings' odds make it one of the best NCAAF betting apps around. So, if you want to follow our spread pick today, understand at -110 odds a $110 bet profits $100 if Louisville wins by 10 points or more.
Murray State vs. Louisville Score Last Week
Finally, to fully round out our Louisville vs. Indiana prediction, let’s take a look at the aforementioned Cardinals performance last week:
- Murray State Racers 0 vs. Louisville Cardinals 56
That final score certainly supports our Louisville vs. Indiana prediction, so make sure you take full advantage by signing up at DraftKings for your guaranteed $200 in bonus bets.
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