The Bills will face the Bears in Chicago for each team's opening game of the 2014-15 NFL season.
The Bears finished last season in second place in the NFC North at 8-8. They did not make the playoffs.
The Bills, under new head coach Doug Marrone, finished 6-10 last season. Buffalo has not made the playoffs for 14 straight seasons.
Details for Sunday's game are below:
Kickoff: 1:00 p.m. ET
Live stream: The game can be live streamed through NFL Sunday Ticket.
TV coverage: FOX
Chicago Bears facts
The Bears will open at home for the fifth straight year. Before that, they began the previous five seasons on the road.
If the Bears win on Sunday, they will have won five straight season openers for the first time since they won nine straight from 1984-92, when Mike Ditka was the team's head coach.
Last season, the Bears scored 18.2 points per game, which ranked 18th in the league.
Running back Matt Forte led the team in rushing, with 1,339 yards on 289 carries. He ran for nine touchdowns.
Devin Hester, who spent eight seasons with the Bears and leads the league all-time with 13 punt returns for touchdowns, left for Atlanta in March. Hester said last month that he didn't have a choice to stay in Chicago.
Last season, Hester led the Bears' returning corps with 52 kick returns for 1,436 yards. He also contributed 18 punt returns and a touchdown.
Receiver Brandon Marshall had 100 catches for 1,295 yards and 12 touchdowns to lead the team. Fellow wideout Alshon Jeffrey added 89 catches for 1,421 and 7 touchdowns.
Buffalo Bills facts
The Bills scored just 12.6 points per game in 2013, worst in the NFL.
Last season, quarterback EJ Manuel threw for 1,972 yards and 11 touchdowns. He had a quarterback rating of 77.7.
Running back Fred Jackson ran for nine touchdowns and 890 yards on 206 carries last season.
The Bills' 284.4 yards per game in 2013 ranked 25th in the NFL.
The Bills' defense finished the season at plus-three in turnovers. Defensive end Jerry Hughes forced two fumbles. Four players each contributed four interceptions.
Buffalo Bills receiver Sammy Watkins has been dealing with bruised ribs this preseason, but hopes to play on Sunday.
Bills players voted for team captains, and Manuel was not one of them. Cornerback Corey Graham, running back Fred Jackson, linebacker Brandon Spikes, defensive tackle Kyle Williams, defensive end Mario Williams and center Eric Wood were all voted as team captains.
The Bills had 57 sacks last season. Defensive end Mario Williams had 13.0.
- Sarah Barshop