Betting - San Francisco 49ers On SI - Sports Illustrated

Betting

Sep 28, 2025; Santa Clara, California, USA; San Francisco 49ers head coach Kyle Shanahan walks off of the field after the game against the Jacksonville Jaguars at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

Kyle Shanahan reveals how he would handle a 49ers player dropping the ball for a fumble before crossing the goal line.

Sep 28, 2025; Santa Clara, California, USA; San Francisco 49ers head coach Kyle Shanahan walks off of the field after the game against the Jacksonville Jaguars at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

News

Kyle Shanahan reveals how he would handle a 49ers player dropping the ball for a fumble before crossing the goal line.

Recent Articles

Jun 10, 2025; Santa Clara, CA, USA; San Francisco 49ers offensive tackle Trent Williams (71) reacts to a blocking drill during an OTA at Levi's Stadium. Mandatory Credit: D. Ross Cameron-Imagn Images

News

Here is where 49ers star Trent Williams stacks up as a favorite to win the NFL Protector of the Year award.

Jun 11, 2025; Santa Clara, CA, USA; San Francisco 49ers running back Christian McCaffrey (23) runs a play from scrimmage during a team OTA at Levi's Stadium. Mandatory Credit: D. Ross Cameron-Imagn Images

Betting

49ers star Christian McCaffrey is looking to bounce-back significantly in 2025, making him a prime candidate for NFL Comeback Player of the Year.

Jan 5, 2025; Glendale, Arizona, USA; San Francisco 49ers defensive end Nick Bosa (97) against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images

Betting

49ers star Nick Bosa has been a favorite to win the NFL Defensive Player of the Year award for the last five years.

Nov 17, 2024; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) rushes the ball while be pursued by Seattle Seahawks linebacker Derick Hall (58) in the fourth quarter at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

Betting

49ers star Christian McCaffrey is getting a decent shot to win back his NFL Offensive Player of the Year award from 2023.

Jun 10, 2025; Santa Clara, CA, USA; San Francisco 49ers head coach Kyle Shanahan watches his players work out during an OTA at Levi's Stadium. Mandatory Credit: D. Ross Cameron-Imagn Images

Betting

49ers head coach Kyle Shanahan usually is a favorite to win the NFL Coach of the Year award.

May 9, 2025; Santa Clara, CA, USA; San Francisco 49ers defensive lineman Mikel Williams (98) bats at a ball as part of a rushing drill during the teamís rookie minicamp. Mandatory Credit: D. Ross Cameron-Imagn Images

Betting

Mykel Williams is the first 49ers rookie to have this much hype since Nick Bosa in 2019.

Dec 8, 2024; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) throws a pass during the first quarter against the Chicago Bears at Levi's Stadium. Mandatory Credit: Bob Kupbens-Imagn Images

Betting

The 49ers are surprisingly one of the favorites to win the Super Bowl this upcoming season.

Sep 9, 2024; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) warms up in the fourth quarter against the New York Jets at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

Betting

If you think 49ers QB Brock Purdy is going to have a stellar 2025 season, then you might want to bet on him to win the NFL MVP award.

Dec 30, 2024; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) celebrates after scoring a touchdown during the second quarter against the Detroit Lions at Levi's Stadium. Mandatory Credit: Sergio Estrada-Imagn Images

Betting

It seems a lot of bettors like the 49ers to emerge as the best team in the NFC.

Sep 22, 2024; Inglewood, California, USA; San Francisco 49ers quarterback Brock Purdy (13) throws a pass in the second half at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Betting

The 49ers are the betting favorites to win the NFC West, and it is likely tied to this factor.

Dec 12, 2024; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) throws the ball against the Los Angeles Rams during the first quarter at Levi's Stadium. Mandatory Credit: Kelley L Cox-Imagn Images

News

It's surprising to see the 49ers have these betting odds to win the NFC West.

Feb 11, 2024; Paradise, Nevada, USA; San Francisco 49ers running back Christian McCaffrey (23) runs with the ball against Kansas City Chiefs safety Mike Edwards (21) during overtime of Super Bowl LVIII at Allegiant Stadium. Mandatory Credit: Joe Camporeale-USA TODAY Sports

Betting

The NFL MVP award is essentially the "best quarterback" award, yet Christian McCaffrey managed to become a finalist for it in 2023. Can he contend for it again in 2024?

Feb 5, 2024; Las Vegas, NV, USA; San Francisco 49ers head coach Kyle Shanahan speaks during Super Bowl LVIII Opening Night at Allegiant Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports

Betting

The NFL Coach of the year award is an accolade that Kyle Shanahan should've had by now. Will 2024 be the year he finally attains it?

Feb 11, 2024; Paradise, Nevada, USA; San Francisco 49ers wide receiver Deebo Samuel (19) runs with the ball against the Kansas City Chiefs LVIII between Kansas City Chiefs and San Francisco 49ers at Allegiant Stadium. Mandatory Credit: Joe Camporeale-USA TODAY Sports

Betting

Deebo Samuel was knocking on the door of a 1,000 yard receiving season in 2023, so eclipsing the over/under of 775.5 yards set by DraftKings sportsbook in 2024 should be easy then right?

Feb 11, 2024; Paradise, Nevada, USA; San Francisco 49ers running back Christian McCaffrey (23) runs with the ball against Kansas City Chiefs safety Mike Edwards (21) during overtime of Super Bowl LVIII at Allegiant Stadium. Mandatory Credit: Joe Camporeale-USA TODAY Sports

Betting

Christian McCaffrey was able to eclipse 500 yards receiving last year, but can he do it again 2024?

Jan 28, 2024; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) runs with the ball against Detroit Lions safety C.J. Gardner-Johnson (2) during the first half of the NFC Championship football game at Levi's Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports

Betting

Will Christian McCaffrey have another monstrous season on the ground for rushing yards as the lead star for the 49ers again?

Jan 28, 2024; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) is introduced before the NFC Championship football game against the Detroit Lions at Levi's Stadium. Mandatory Credit: Kelley L Cox-USA TODAY Sports

Betting

Nick Bosa will be seeking to starting off 2024 strong as opposed to 2023. Doing so could make a difference for him to regain the Defensive Player of the Year award that he won in 2022. Here are his odds to win it.

Feb 11, 2024; Paradise, Nevada, USA; San Francisco 49ers running back Christian McCaffrey (23) runs with the ball against Kansas City Chiefs safety Mike Edwards (21) during overtime of Super Bowl LVIII at Allegiant Stadium. Mandatory Credit: Joe Camporeale-USA TODAY Sports

Betting

Christian McCaffrey went off for a resounding 14 rushing touchdowns in 2023. DraftKings sportsbook expects another great year for him in this stat as they have set the over/under at 10.5.

Jan 28, 2024; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) warms up before the NFC Championship football game against the Detroit Lions at Levi's Stadium. Mandatory Credit: Kelley L Cox-USA TODAY Sports

Betting

DraftKings sportsbook has set the over/under for passing yards at 3,900.5 for Brock Purdy in 2024. He threw for 4,280 yards in 2023, which was a 49ers single-season record. Can he eclipse 4,000 yards again?

Dec 25, 2023; Santa Clara, California, USA; San Francisco 49ers wide receiver Brandon Aiyuk (11) runs with the ball next to Baltimore Ravens linebacker Patrick Queen (6) in the fourth quarter at Levi's Stadium. Mandatory Credit: Cary Edmondson-USA TODAY Sports

Betting

Brandon Aiyuk is coming off a season where he put up a career high in receiving yards with 1,342 as a secondary option on the 49ers. Yet, DraftKings sportsbook set his over/under at 950.5 yards.

Dec 31, 2023; Landover, Maryland, USA; San Francisco 49ers wide receiver Brandon Aiyuk (11) celebrates after scoring a touchdown against the Washington Commanders during the second half at FedExField. Mandatory Credit: Brad Mills-USA TODAY Sports

Betting

DraftKings sportsbook has set the over/under for receiving touchdowns at 5.5 for 49ers' Brandon Aiyuk. Will he eclipse that or fall short?

Feb 11, 2024; Paradise, Nevada, USA; San Francisco 49ers quarterback Brock Purdy (13) throws a pass against the Kansas City Chiefs in the second half in Super Bowl LVIII at Allegiant Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports

Betting

DraftKings sportsbook has set the over/under at 28.5 passing touchdowns for 49ers' Brock Purdy this upcoming season. Does he eclipse it or fall short?

Feb 11, 2024; Paradise, Nevada, USA; San Francisco 49ers quarterback Brock Purdy (13) hands the ball to running back Christian McCaffrey (23) against the Kansas City Chiefs during overtime of Super Bowl LVIII at Allegiant Stadium. Mandatory Credit: Joe Camporeale-USA TODAY Sports

Betting

DraftKings sportsbook has set the over/under at 11.5 wins for the 49ers in 2024. They barely edged that out last season with 12. Will they eclipse 11.5 again?

49ers NFL Odds: Latest Betting on Super Bowl, Playoffs & Futures

Betting

Stay updated with the latest 49ers NFL betting odds. Our experts provide insights on their Super Bowl odds, playoff chances, and much more.