Whisenhunt, 51, takes over for Mike Munchak who was fired on Jan. 4 after three seasons with the team. Whisenhunt was with the Chargers for only one season.
“Ken is a well-respected coach in this league. I’m looking forward to seeing his vision become reality," said Titans CEO Tommy Smith.
He is 45-51 as an NFL head coach, spending six seasons with the Arizona Cardinals, leading them to two playoff berths and a Super Bowl appearance. Whisenhunt was rumored to be in line for the vacant Detroit Lions head coaching job.