You can follow the game with live stats and play-by-play here.
Details for Sunday's game are below:
Kickoff: 8:30 p.m. ET
Live stream: The game can be live streamed here.
TV coverage: NBC
Odds: The 49ers are seven-point favorites, according to Bovada, as of Friday.
San Francisco 49ers facts
The 49ers lead the all-time series against the Bears, 32-29-1. In the regular season, the teams are tied at 29-29-1. The 49ers beat the Bears in the team's first win during their 1971 inaugural season at Candlestick Park.
Sunday's game will be the first regular-season game played at Levi’s Stadium in Santa Clara, the new home of the 49ers.
Kaepernick was 16-for-23 for 201 yards, with a quarterback rating of 125.5.
Kaepernick made his first NFL start against the Bears on Monday Night Football in Week 10 of 2012.
Running back Frank Gore led the team with 66 yards on 16 carries.
Running back Carlos Hyde had the 49ers' lone rushing touchdown. He ran for 50 yards on seven attempts.
The 49ers defense forced four turnovers. Cornerback Chris Culliver returned a fumble 35 yards for a touchdown.
San Francisco tight end Vance McDonald wears No. 89 because head coach Jim Harbaugh said he reminded him of what he saw in Mike Ditka when he played.
Harbaugh was the Bears' first-round draft pick in 1987. He went 1-3 against the 49ers as a player, and is now 1-0 against the Bears as a head coach.
Chicago Bears facts
Since 1985, the Bears have lost all eight games against the 49ers in San Francisco. All were played at Candlestick Park.
San Francisco beat Chicago 32-7 the last time the two teams played, on Nov. 19, 2012 at Candlestick Park. Backup quarterback Jason Campbell played for Cutler, who was out with a concussion, and was sacked six times. In the game, linebacker Aldon Smith recorded 5.5 sacks, which is a single-game record for a Bears opponent.
Bears quarterback Jay Cutler has played the 49ers twice in his career. In those two games, Cutler has completed 50 of 84 passes for 537 yards and a 52.5 quarterback rating. Cutler also has a touchdown and six interceptions.
In the Bears' Week 1 loss to Buffalo, they compiled 427 total yards, which was the fourth-most in Week 1. The three teams who had more yards than the Bears all scored at least 30 points.
Against the Bills, Cutler was 34-for-49 for 349 yards, two touchdowns, and two interceptions.
The Bears' offense committed three turnovers, which led to 13 points for the Bills.
This game, which will be on NBC's Sunday Night Football, is the first of back-to-back games on primetime for the Bears. Chicago will play the Jets on Monday Night Football in Week 3.
Before Sunday's loss, the Bears had won four straight season openers for the first time since they won nine straight from 1984-92, when Mike Ditka was the team's head coach.
In 1995, head coach Marc Trestman was the 49ers offensive coordinator and quarterbacks coach.
- Sarah Barshop