Kyle Isbel, Juan Soto Headline PrizePicks Plays For Thursday's MLB Slate

These are four of the top PrizePicks plays for users to consider ahead of the MLB's four-game slate on Thursday.

Apr 1, 2026; St. Louis, Missouri, USA; New York Mets left fielder Juan Soto (22) reacts after hitting a solo home run against the St. Louis Cardinals during the sixth inning at Busch Stadium. | Jeff Curry-Imagn Images

MLB regular season action continues on Thursday night, with six teams set to suit up for a highly anticipated three-game slate. Some of baseball’s biggest stars, including Ronald Acuna Jr. and Juan Soto, will take the national stage for Thursday’s slate, presenting some of the most popular PrizePicks props of the week thus far. Soto and Acuna are shining to start the year, but several other players could help PrizePicks users cash in on Thursday night. Let’s look at five of the top PrizePicks plays for tonight’s matchups: 

Juan Soto Over 1.5 Hits+Runs+RBIs

Apr 1, 2026; St. Louis, Missouri, USA; New York Mets left fielder Juan Soto (22) hits a solo home run against the St. Louis Cardinals during the sixth inning at Busch Stadium. | Jeff Curry-Imagn Images

Soto has been on a tear to open his 2026 campaign, playing a crucial role in the New York Mets’ 3-3 start to the season. Through six games, Soto is hitting .346, racking up nine hits, two doubles, a home run and five RBIs. He’s racked up at least one hit in each game to start the year, a trend that projects to continue against a struggling San Francisco Giants defense. He’s averaging 2.1 Hits/Runs/RBIs per game and will carry his recent momentum into Thursday night’s matchup. 

Bobby Witt Jr. Over 0.5 Hits

After dropping back-to-back games to open the year, the Kansas City Royals have rebounded in a big way, racking up wins in each of their last three games. Bobby Witt Jr. has played a key role in a red-hot Royals offense, hitting a respectable .278 from the plate with five hits in as many games. He’s posted at least one hit in four of Kansas City’s first five contests and will look to extend his production from the plate against a struggling Minnesota Twins squad. Witt should continue his hit surge on Thursday night, presenting a favorable line for PrizePicks users.

Taj Bradley Over 4.0 Strikeouts

Mar 28, 2026; Baltimore, Maryland, USA; Minnesota Twins pitcher Taj Bradley (26) delivers during the first inning against the Baltimore Orioles at Oriole Park at Camden Yards. | Mitch Stringer-Imagn Images

Twins starter Taj Bradley is slated to make his second start of the year coming off a dominant performance in his season debut. The 25-year-old racked up nine strikeouts in 4.1 innings, allowing just three hits and one run during his stretch on the mound. Entering Thursday’s game against the Royals, many are expecting Bradley to build on his stellar opener, presenting an immensely favorable line of just four strikeouts. His prop is the most popular of Thursday’s slate, with over 12 thousand bets at the time of publishing. 

Kyle Isbel Over 0.5 Singles

Reverting to Kansas City’s hot start, the team has noticed a strong performance from outfielder Kyle Isbel. Isbel is hitting at an eyebrow-raising .571 mark over four games, posting eight hits, four runs, two homers and four RBIs to this point of the season. He’s coming off a dominant four-hit game against the Twins on Wednesday, and should carry such momentum into the third game of the series on Thursday. Users should feel tremendous optimism in his 0.5 singles PrizePicks mark for today’s matchup.