Louisville Opens as Road Favorite vs. Pitt

The Cardinals travel to the Steel City to face the Panthers in their ACC opener.
Nov 23, 2024; Louisville, Kentucky, USA;  Louisville Cardinals linebacker Stanquan Clark (6) and linebacker TJ Quinn (34) tackle Pittsburgh Panthers running back Desmond Reid (0) during the first half at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images
Nov 23, 2024; Louisville, Kentucky, USA; Louisville Cardinals linebacker Stanquan Clark (6) and linebacker TJ Quinn (34) tackle Pittsburgh Panthers running back Desmond Reid (0) during the first half at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images | Jamie Rhodes-Imagn Images

LOUISVILLE, Ky. - The Louisville football program might have to hit their road for the first game in ACC play this season, but oddsmakers are liking them to continue their undefeated start when they face Pitt.

According to FanDuel, the Cardinals have opened up as a 6.5-point favorite over the home Panthers. The over/under has been set at 53.5.

While the Cardinals have still yet to face a power conference team this season, they've looked good so far in year three under head coach Jeff Brohm, winning their first three games by a combined score of 119-48. This includes a 51-17 victory over in-state FCS foe Eastern Kentucky, a comeback 28-14 win against James Madison and most recently a three-phase 40-17 win against Bowling Green.

As for the Panthers, they had a hot start to the season before running into a bump in the road. Facing Duquesne and Central Michigan to start the season, Pitt won both in blowout fashion, out-scoring the Dukes and Chippewas by a combined 106 to 26 points. However, they most recently traveled to Morgantown for the Backyard Brawl, and were dealt a 31-24 overtime loss by West Virginia.

Louisville is 0-3 against-the-spread so far this season, whereas Pitt is 2-1. The Cardinals have yet to play a game on the road, while the Panthers are 2-0 at home both ATS and straight up.

The Cardinals were unable to cover vs. Eastern Kentucky (-38.5), vs. James Madison (-15.5) and vs. Bowling Green (-26.5); while the Panthers covered at Cincinnati (+22.5) and vs. Liberty (+6.5), but were unable to do so vs. Lafayette (-21.5).

Kickoff vs. Pitt is scheduled for Saturday, Sept. 27 at 12:00 p.m. EST.

Game odds refresh periodically and are subject to change. 

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

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(Photo of Desmond Reid, T.J. Quinn: Jamie Rhodes - Imagn Images)

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Matthew McGavic
MATTHEW MCGAVIC

McGavic is a 2016 Sport Administration graduate of the University of Louisville, and a native of the Derby City. He has been covering the Cardinals in various capacities since 2017, with a brief stop in Atlanta, Ga. on the Georgia Tech beat. He is also a co-host of the 'From The Pink Seats' podcast on the State of Louisville network. Video gamer, bourbon drinker and dog lover. Find him on Twitter at @Matt_McGavic