Penn State vs. Iowa odds, spread, lines, Week 4 college football game betting picks

Fresh off a statement win on the road in the Big Ten opener a week ago, No. 7 ranked and undefeated Penn State returns to Happy Valley in a cross-division matchup against 24th ranked Iowa in a battle of top 25 teams in college football's Week 4 action on Saturday.
Penn State forced five turnovers against Illinois a week ago to stay perfect and play a balanced brand of offense, as Drew Allar is averaging 259 yards in the air per game, compared to a stout rushing attack good for 208 yards on the ground.
Iowa's offense is still a work in progress as quarterback Cade McNamara is a 54 percent passer through three games behind an offense good for 302 yards per game.
Here are the early lines and betting trends you should know about as the Hawkeyes take it on the road against the Nittany Lions this weekend.
Penn State vs. Iowa game odds
Courtesy of FanDuel
Line: Penn State -14
Total: 40.5 (O -115, U -105)
ML: PSU -630 | Iowa +450
FPI pick: Penn State 86.8% to win
Betting trends
+ Iowa is 7-2 against the spread in its last 9 games
+ Penn State is 9-0-1 ATS in its last 10 games
+ Total went under in 6 of Iowa's last 8 games
+ Total went over in 5 of PSU's last 7 vs. Iowa
+ Hawkeyes are 6-1 ATS in their last 7 road games
+ Penn State is 6-1 ATS in its last 7 September games
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Penn State vs. Iowa schedule
When: Sat., Sept. 23
Time: 7:30 p.m. Eastern
TV: CBS network
Stream live: fuboTV (Try for free)
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James Parks is the founder and publisher of College Football HQ. He has covered football for a decade, previously managing several team sites and publishing national content for 247Sports.com for five years. His work has also been published on CBSSports.com. He founded College Football HQ in 2020, and the site joined the Sports Illustrated Fannation Network in 2022 and the On SI network in 2024.