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Clemson vs. Syracuse picks, predictions: Week 5 college football game odds, lines

Expert predictions for Clemson vs. Syracuse by the computer analytic models that pick college football games
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Coming off the second loss of its season and slipping out of the playoff conversation, unranked Clemson goes on the road against undefeated Syracuse in a battle of ACC rivals as college football's Week 5 action kicks off on Saturday.

That costly, second loss came at home against Florida State, which broke a seven-game losing skid in the series, and moved into pole position in not only the ACC conference title race, but also the College Football Playoff hunt. Cade Klubnik is a 66 percent passer for Clemson, which averages 474 total yards per game.

Syracuse posts over 507 yards on offense each time out behind a balanced attack that averages 213 rushing yards per game and boasts a road win against a Power Five opponent after defeating Purdue by 15 points two weeks ago.

What do the experts think of the matchup? Let's see how the College Football Power Index computer prediction model projects the game.

Clemson vs. Syracuse picks, predictions

Clemson Tigers running back Will Shipley on a rushing attempt during a college football game in the ACC.

Clemson vs. Syracuse picks, predictions

Syracuse odds: The computers are predicting an upset as the Orange have the projected 55.1 percent chance to win, according to the computers that simulate games 20,000 times to pick winners.

Clemson odds: Conversely, the Tigers are forecasted to win the game in 44.9 percent of the simulations, according to the latest models.

Point spread: The bookies take a different view, naming Clemson as the 6.5 point favorites against Syracuse, according to the lines at SI Sportsbook, which set the total at 53.5 points.

Clemson predictions: The index forecasts that Clemson will be 14.1 points better than an average opponent and estimates it will win 6.8 games this season, with a meager 1.8 percent chance of winning out.

Syracuse predictions: Down 4 spots in the index rankings despite the win, the models forecast the Orange to be 13.4 points better than opponents and projected to win 9.4 games this season.

College Football Power Index

Football Power Index (FPI) college football rankings and computer prediction model are a measure of team strength that predicts a team’s future performance.

Rankings and scores predictions are based on 20,000 simulations of a team’s season and games, using a combination of key analytics, including scores to date, quality of opponents, team talent, recruiting, and a team’s schedule.

Teams are ranked not strictly in order of talent like in other rankings, but by a projected point margin per game against an average team on a neutral field.

Clemson vs. Syracuse schedule

When: Sat., Sept. 30
Time: 12 p.m. Eastern
TV: ABC network
Stream live: fuboTV (Try for free)

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College football rankings

According to AP top 25 poll

  1. Georgia
  2. Michigan
  3. Texas
  4. Ohio State
  5. Florida State
  6. Penn State
  7. Washington
  8. USC
  9. Oregon
  10. Utah
  11. Notre Dame
  12. Alabama
  13. LSU
  14. Oklahoma
  15. North Carolina
  16. Washington State
  17. Duke
  18. Miami
  19. Oregon State
  20. Ole Miss
  21. Tennessee
  22. Florida
  23. Missouri
  24. Kansas
  25. Fresno State

More college football from SI: Top 25 Rankings | Schedule | Teams

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