Week 12 Fantasy Football Quarterback Starts: Jacoby Brissett, Bryce Young and More

Here are four quarterbacks who should be in fantasy football starting lineups in Week 12 of the NFL season.
Nov 16, 2025; Atlanta, Georgia, USA; Carolina Panthers quarterback Bryce Young (9) reacts to a touchdown in the fourth quarter against the Atlanta Falcons at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-Imagn Images
Nov 16, 2025; Atlanta, Georgia, USA; Carolina Panthers quarterback Bryce Young (9) reacts to a touchdown in the fourth quarter against the Atlanta Falcons at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-Imagn Images | Brett Davis-Imagn Images

Picking the right quarterback every week could be the edge that swings your fantasy football matchup. With that being said, Week 12 of the NFL season offers several favorable matchups and sneaky upside plays at QB. Below are several options to weigh with analysis on each. 


Check out my Week 12 quarterback sits.

Jared Goff (Lions) vs. Giants

Goff is coming off one of the worst quarterback performances of the season vs. the Eagles on the road in Week 11. He completed 14-of-37 passes (37.8%) and posted a 60.1 passer rating and a 9.5 quarterback rating.  However, Goff and the Lions return home to host the Giants in Week 12. New York has given up the second-most fantasy points to quarterbacks this season. It ranks 11th in passing yards per game but has allowed two passing touchdowns per game over its last three. This is a prime opportunity for Goff to bounce back. 

Detroit Lions quarterback Jared Goff returns to the dome at home in Week 12 vs. the Giants.
Nov 16, 2025; Philadelphia, Pennsylvania, USA; Detroit Lions quarterback Jared Goff (16) reacts against the Philadelphia Eagles during the second half at Lincoln Financial Field. Mandatory Credit: Bill Streicher-Imagn Images | Bill Streicher-Imagn Images

Brock Purdy (49ers) vs. Panthers 

Purdy finally returned to action against the Cardinals after re-aggravating a turf toe injury in Week 4. He looked healthy, throwing for 200 yards and three touchdowns as the 49ers walloped the Cardinals. Although the sample size is small, Purdy has been consistent in his starts this season. He’s averaged over 260 passing yards and thrown for multiple TDs in his three games. The 49ers play the Panthers in Week 12, who’ve been solid against signal callers overall. However, Purdy has a strong floor as a passer. He’s the ultimate floor play with a high chance of scoring in the 18-25 point range. 

San Francisco 49ers quarterback Brock Purdy threw for 200 yards and three touchdowns in his first game back from injury.
San Francisco 49ers quarterback Brock Purdy (13) scrambles out of the pocket against the Arizona Cardinals at State Farm Stadium in Glendale on Nov. 16, 2025. | Joe Rondone/The Republic / USA TODAY NETWORK via Imagn Images

Jacoby Brissett (Cardinals) vs. Jaguars

As everyone expected, Brissett has taken the starting job under center for Arizona and balled out. He’s scored 19.4 or more fantasy points in every start since Week 6 and is coming off a 21.88-point outing where he set the record for completions in an NFL game. Brissett has been consistent, unlike Kyle Murray. The veteran has thrown two touchdowns in all five of his starts and is averaging over 300 passing yards per game. Brissett and the Cardinals face the Jaguars in Week 12. Although they shut down Justin Herbert in Week 11, they rank inside the top in terms of fantasy points allowed to QBs. Look for Brissett to continue his redemption tour as a result. 

Arizona Cardinals quarterback Jacoby Brissett set an NFL record with 47 completions vs. the San Francisco 49ers in Week 11.
Arizona Cardinals quarterback Jacoby Brissett (7) takes the field before their game against the San Francisco 49ers at State Farm Stadium on Glendale on Nov. 16, 2025. | Joe Rondone/The Republic / USA TODAY NETWORK via Imagn Images

Bryce Young (Panthers) @ 49ers

Young is coming off his best performance as a pro. He put up a career-high 448 passing yards and three touchdowns against a stout Falcons defense as he and the Panthers defeated them, 30-27. Young netted 31.82 fantasy points, which was by far his best fantasy performance of the season. He and the Panthers play the 49ers in Week 12. San Francisco is coming off a week in which it surrendered 452 passing yards to Brissett. It also now ranks fifth in passing yards per game (249.1). Young had his two worst games before his Week 11 breakout, but newfound confidence paired with an advantageous matchup has the makings of a solid fantasy outing this week. 

Carolina Panthers quarterback Bryce Young is coming off his best performance as a pro.
Nov 16, 2025; Atlanta, Georgia, USA; Carolina Panthers quarterback Bryce Young (9) runs off the field in the third quarter against the Atlanta Falcons at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-Imagn Images | Brett Davis-Imagn Images

Check out our Week 12 quarterback rankings.    

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Michael Rovetto
MICHAEL ROVETTO

Michael Rovetto previously served as the staff writer for University of Maryland Athletics for nearly two years. There, he wrote, edited and managed all editorial content for all 20 of Maryland's varsity sports on umterps.com. Rovetto is recognized as a College Sports Communicators district award-winning writer. Many of his stories have also appeared on NCAA.org, garnering national attention. Before graduating from Maryland's Philip Merrill College of Journalism in December 2023, Rovetto wrote for PressBox and Terrapin Sports Central, covering Maryland men's basketball and football. He also has experience in broadcasting, previously working as an analyst and camera operator for Big State Sports, and communication, interning for Shell Shock TBT as its Director of Communication & Content Development.