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Analytics Predicts Colorado Buffaloes' Game-By-Game Results

Here are the individual game-by-game predictions for the Colorado Buffaloes according to analytics.
Oct 25, 2025; Salt Lake City, Utah, USA; Colorado Buffaloes head coach Deion Sanders looks on during a time out in the game against the Utah Utes during the second quarter at Rice-Eccles Stadium. Mandatory Credit: Rob Gray-Imagn Images
Oct 25, 2025; Salt Lake City, Utah, USA; Colorado Buffaloes head coach Deion Sanders looks on during a time out in the game against the Utah Utes during the second quarter at Rice-Eccles Stadium. Mandatory Credit: Rob Gray-Imagn Images | IMAGN IMAGES via Reuters Connect

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The Colorado Buffaloes were rated by ESPN’s Power Football Index (FPI) as the No. 10 team in the Big 12 conference and the No. 45 overall team in the country. Their FPI rating is 4.5.

What does the FPI say about the Buffs’ percentage chance to win each game on their schedule?

colorado buffaloes espn football power index rating prediction big 12 bowl game betting odds deion sanders coach prime fpi
Jul 7, 2026; Frisco, TX, USA; Colorado head coach Deion Sanders speaks to reporters during Big 12 Conference Football Media Days at The Star. Mandatory Credit: Raymond Carlin III-Imagn Images | IMAGN IMAGES via Reuters Connect

Sept. 3: at Georgia Tech Yellow Jackets - 41.5 percent 

On the road against Georgia Tech is a tough way to start the season for Colorado. These two teams faced off in Boulder to open up the 2025 season. The Yellow Jackets won a close game late by a final score of 27-20. The Buffs will try to repay the favor. Colorado failed to win a road game in 2025, which makes the 41.5 percent chance of winning a fair one.

Sept. 12: vs. Weber State Wildcats - 97.7 percent 

A home opener against Weber State is as big of a must-win game as Colorado has on their entire schedule. Losing to an FCS team that they have a 97.7 percent chance of beating could completely derail the season.

Sept. 19: at Northwestern Wildcats - 47.4 percent 

colorado buffaloes espn football power index rating prediction big 12 bowl game betting odds deion sanders coach prime fpi
Nov 22, 2025; Chicago, Illinois, USA; Northwestern Wildcats wide receiver Hayden Eligon II (80) celebrates after a gain of yardage against the Minnesota Golden Gophers during the second half at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images | IMAGN IMAGES via Reuters Connect

Colorado has another non-conference road game that will be a challenge. Northwestern went 7-6 last season and were 4-5 in the Big Ten. FPI gives the slight edge to Northwestern.

Sept. 26: at Baylor Bears - 36.2 percent 

The Buffs open up conference play with a road game at Baylor. It's not an easy task for Colorado and is the hardest game on the schedule to this point per the FPI.

Oct. 3: vs. Texas Tech Red Raiders - 16.4 percent 

colorado buffaloes espn football power index rating prediction big 12 bowl game betting odds deion sanders coach prime fpi
Jul 7, 2026; Frisco, TX, USA; Texas Tech head coach Joey McGuire speaks to reporters during Big 12 Conference Football Media Days at The Star. Mandatory Credit: Raymond Carlin III-Imagn Images | IMAGN IMAGES via Reuters Connect

Texas Tech is the defending Big 12 champion and is currently the favorite to repeat. Even at Folsom Field, it's a long shot for the Buffs to pull off this win.

Oct. 17: vs. Utah Utes - 48.2 percent 

Colorado gets the FPI nod when they welcome in Utah to Boulder. The Utes are one of the more consistent programs in the country but have a new head coach this season.

Oct. 24: at Oklahoma State Cowboys - 46.4 percent  

Oklahoma State went winless in 2025 but made a complete overhaul on the coaching staff. This game being on the road tilts the game in the Cowboys favor.

Oct. 31: vs. Kansas State Wildcats - 55.5 percent 

Colorado ended their season on the road with a loss at Kansas State. Will the game being at home change things in 2026?

Nov. 7: at Arizona State Sun Devils - 41.9 percent 

colorado buffaloes espn football power index rating prediction big 12 bowl game betting odds deion sanders coach prime fpi
Arizona State head coach Kenny Dillingham watches his team as they run drills during a spring practice at Kajikawa practice fields in Tempe, Ariz. on April 14, 2026. | USA TODAY Network via Reuters Connect

Arizona State won the Big 12 in 2024, but took a slight step back in 2025. This is another hard road game for Colorado.

Nov. 13: vs. Houston Cougars - 50.7 percent 

Houston is projected to be one of the better teams in the Big 12 this season. Colorado will hope that their home field can help them prevail in what FPI considers to be a coin-flip game.

Nov. 21: at Cincinnati Bearcats - 41.2 percent 

Cincinnati started out 2025 7-1, but lost their remaining five games. They'll try to make sure they don't have a late season collapse again in 2026.

Nov. 28: vs. UCF Knights - 67.7 percent 

This is Colorado's best chance to win a game in the Big 12. They'll need this one to make a bowl.

FPI's Record Projection: 6.0-6.1

This projection would have Colorado just sneaking into a bowl game. That's a better projection than what sports books have. According to DraftKings Sportsbook, Colorado has a win total of 4.5. The odds are favoring the under at -160. The over is at +134.

Colorado is coming off a 3-9 season in 2025 and will look to return to a bowl game under coach Deion Sanders in 2026.

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

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Cory Pappas
CORY PAPPAS

Cory Pappas is sports writer for USC Trojans On SI, Oregon Ducks On SI and Colorado Buffaloes on SI. Since starting in March of 2024, he has been writing breaking news stories, game previews, game recaps, and more across College Sports, the NFL, MLB, NBA, and Olympics for Total Apex Sports. In addition to writing, Cory is also a sports data scout for Sportradar. He covers live sporting events ranging from college athletics to semi-pro and professional. Before joining the industry, Cory graduated from the University of Oregon in 2022. He ran track for Oregon's club Track and Field team. Before Oregon, he played varsity basketball and track and field in high school in Walnut Creek, CA. Cory is using his lifelong passion for sports and writing together.

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