The Latest Betting Lines: Ole Miss Football vs. LSU Tigers in Top-15 SEC Matchup

Lane Kiffin and Co. will look to make a statement, square off against the Bayou Bengals at home.

Sep 20, 2025; Oxford, Mississippi, USA; Mississippi Rebels quarterback Trinidad Chambliss (6) drops back to pass during the second quarter against the Tulane Green Wave at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images | Petre Thomas-Imagn Images

No. 13 Ole Miss will return to Vaught-Hemingway Stadium on Saturday for the program's Week 5 SEC clash against Brian Kelly's LSU Tigers.

In a matchup that has been nothing short of thrilling across the last few years, Lane Kiffin and Co. will look to get back in the win column after falling to the Bayou Bengals in 2024.

Heading into Saturday, all eyes will be on the Ole Miss offense with quarterback Trinidad Chambliss in line to take on starting duties once again for the Rebels in his third consecutive game.

The Ferris State transfer was thrown in the mix against the Arkansas Razorbacks in Week 3 where he handled business in his first Division I start.

Chambliss has thrown for over 700 yards and four touchdowns across two starts - while totaling 195 yards and two scores on the ground.

Courtesy of Ole Miss Rebels Football.

The key statistic for the Division II All-American transfer - zero turnovers. Chambliss has played clean football and hasn’t turned the ball over while completing nearly 68 percent of his passes.

The 6-foot, 200-pounder is No. 1 in the SEC in yards per pass attempt (11.6) and No. 2 in passer rating where he's led the Rebels to back-to-back wins over Arkansas and Tulane.

Now, Chambliss is in line to earn the start on Saturday against Kelly and the No. 4 ranked LSU Tigers in Week 5 with the dual-threat signal-caller eyeing his third consecutive win.

With game day inching closer, Vegas has adjusted the betting lines once again with the Rebels set to enter the clash as the favorites.

Courtesy of Ole Miss Rebels Football.

The Game Information: Week 5 Edition

Matchup: Ole Miss Rebels vs. LSU Tigers
Kickoff Time: 2:30 p.m. CT
Venue: Vaught Hemingway Stadium - Oxford (Miss.)
TV Channel: ABC
Radio: Ole Miss Sports Radio Network
LSU Tigers Record: 4-0 (1-0 SEC)
Ole Miss Rebels Record: 4-0 (2-0 SEC)

Odds, Spread and Total: Week 5 Edition

Odds via DraftKings Sportsbook

Spread

• LSU: +1.5 (-108)
• Ole Miss: -1.5 (-112)

Moneyline

• LSU: +105
• Ole Miss: -125

Total

• Over: 56.5 (-112)
• Under 56.5 (-108)

The Ole Miss Rebels will enter the Week 5 clash as 1.5-point favorites, according to DraftKings Sportsbook.

Courtesy of Ole Miss Rebels Football.

No. 13 Ole Miss will return to action on Saturday against No. 4 LSU with the stage set for a Top-15 matchup at Vaught Hemingway Stadium. Kickoff is set for 2:30 p.m. CT.

More Ole Miss News:

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Alabama Head Coach Betting Odds: Ole Miss Football's Lane Kiffin Listed as a Favorite

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