South Carolina vs Missouri Betting Odds: Gamecocks a Massive Underdog

The South Carolina Gamecocks open the week as a massive underdog vs Missouri.
Sep 6, 2025; Columbia, South Carolina, USA; South Carolina Gamecocks head coach Shane Beamer directs his team against the South Carolina State Bulldogs in the second quarter at Williams-Brice Stadium. Mandatory Credit: Jeff Blake-Imagn Images
Sep 6, 2025; Columbia, South Carolina, USA; South Carolina Gamecocks head coach Shane Beamer directs his team against the South Carolina State Bulldogs in the second quarter at Williams-Brice Stadium. Mandatory Credit: Jeff Blake-Imagn Images | Jeff Blake-Imagn Images

The South Carolina Gamecocks open the week as a massive underdog vs Missouri.

It was a tough week three showing from the South Carolina Gamecocks. They took a home loss against the Vanderbilt Commodores by a final score of 31-7 and on top of that, quarterback LaNorris Sellers left the game with a concussion. It was hard for the Gamecocks to get anything going on Saturday and they are looking to bounce back against the Missouri Tigers in week four.

As a result of the weekend, South Carolina went from ranked inside the top 15 to unranked in the AP poll rankings. Missouri, on the other hand, moved up two spots to No. 23. This will be the Gamecocks' first road trip of the season, and accoridng to the betting odds, it's going to take a lot for them to walk out of Missouri with a win.

South Carolina is listed as a 12.5-point underdog against the Missouri Tigers, according to Fan Duel. The over/under is set at 46.5 points.

Last year's matchup between the two teams came down to the wire. The Gamecocks were down by three late in the fourth quarter and Raheim Sanders broke a 15-yard touchdown to take a four-point lead with 15 seconds left. South Carolina at one point held a 21-6 lead during the game.

With one blemish on the record, the Gamecocks likely can't afford to lose more than one more game if they want to keep their college football playoff hopes intact. So that puts a lot of emphasis on this weekend, considering what the rest of their schedule looks like this season.

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Jonathan Williams
JONATHAN WILLIAMS

Jonathan Williams is a multimedia sports journalist who graduated from the University of Georgia with a degree in Journalism. He has multiple years of experience in covering college football for a variety of teams

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