College football Week 5 game picks, predictions from ESPN GameDay

This weekend brings us some impactful games across the conference and playoff conversation with three head-to-head matchups between teams in the AP top 25 rankings and plenty on the line as we close out the month of September on the college football calendar. Now it's time to lock in our final game predictions for today.

Rankings: AP | Coaches | ESPN

Here's your look at the straight-up game picks from the crew on ESPN's College GameDay along with our own updated game predictions from College Football HQ.

College football Week 5 picks

Michigan State at Iowa: Most picks going with the Hawkeyes to get back on the winning side at home this week after getting blanked by Penn State.

Kansas at Texas: A unanimous decision in favor of the Longhorns by the four analysts to stay undefeated against the Jayhawks.

South Carolina at Tennessee: Desmond Howard was the lone vote for the Gamecocks while the other three chose the Volunteers to win at home.

LSU at Ole Miss: All four are going with LSU to take down the Rebels.

Texas A&M at Arkansas: Three of the four votes going with the Razorbacks against the Aggies, while Howard took A&M to win.

Florida at Kentucky: Lee Corso and Kirk Herbstreit voted for Kentucky to hold serve at home while the other two picks went to the Gators.

Clemson at Syracuse: Howard and Corso predict Syracuse will pull off the upset at home.

USC at Colorado: Everyone on GameDay sides with the Trojans against the Buffaloes.

Notre Dame at Duke: Howard and McAfee project Duke will upset the Fighting Irish.

Lee Corso's Headgear Pick: Notre Dame over Duke

College Football HQ picks...

What to watch: CFB Week 5 best games to watch

ATS predictions: Week 5 picks against the spread

Be warned: College football upset alert for Week 5

Analytics picks: Computer model predicts Week 5 games

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