College football Week 6 picks from ESPN's College GameDay

As the Week 6 college football schedule kicks off today, the guys on ESPN’s College GameDay reveal their final picks for the biggest games across the country.

There’s one head-to-head matchup involving ranked teams on the same field today, coming out of the SEC as Missouri looks to solidify its top-10 ranking against Texas A&M at Kyle Field.

Elsewhere in the Big Ten, No. 10 Michigan takes its first road trip of the season, matching up against a solid Washington team in a rematch of last season’s national championship game.

And in the SEC, we’ll watch Ole Miss look to avoid falling to 0-2 in conference play against a good South Carolina defense on the road, while Georgia and Auburn renew the Deep South’s Oldest Rivalry.

Let’s take a turn around the country and lock in our final picks for the biggest games today with the help of the analysts on ESPN’s College GameDay.

College football Week 6 picks

Virginia Tech at Stanford: Kirk Herbstreit was the lone voice in favor of the Cardinal upsetting the Hokies in this new-look ACC matchup.

SMU at Louisville: Herbstreit was again the only one going against the grain here, picking the Mustangs to hand the Cardinals what would be their second-straight loss.

Navy at Air Force: Desmond Howard and guest picker Marshawn Lynch went with the Falcons to hand the Midshipmen what would be their first loss.

Texas Tech at Arizona: Lynch went with the Red Raiders while the others stuck with the Wildcats.

Michigan at Washington: Despite the oddsmakers listing the Huskies as the favorite, everyone on GameDay is going with the Wolverines to upset.

Rutgers at Nebraska: Herbstreit and Lynch are sticking with the Cornhuskers against the undefeated Scarlet Knights.

Iowa at Ohio State: A unanimous vote in favor of the Buckeyes in this Big Ten matchup against the Hawkeyes' strong defense.

UCF at Florida: Saban, Lynch, and Herbstreit picked the Gators to hold on at home against the Knights and their powerful rushing attack.

Ole Miss at South Carolina: Saban and Herbstreit picked the Gamecocks to hand the Rebels what would be a second-straight loss and an 0-2 start in SEC play.

Missouri at Texas A&M: Saban, Herbstreit, and Lynch are siding with Mizzou to beat the Aggies on the road in this battle of ranked SEC hopefuls.

Miami at Cal: Pat McAfee and Lynch were the outliers in picking Cal to upset the Hurricanes.