Expert Computer Model Reveals Score Prediction for Ole Miss Football vs. LSU Tigers

Lane Kiffin and Co. will hot the LSU Tigers in Week 5, preparing for significant challenge as heart of SEC play arrives.

Sep 20, 2025; Oxford, Mississippi, USA; Mississippi Rebels quarterback Trinidad Chambliss (6) drops back to pass during the first quarter against the Tulane Green Wave at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images | Petre Thomas-Imagn Images

No. 13 Ole Miss (4-0, 2-0 SEC) will return to action on Saturday at Vaught Hemingway Stadium for an SEC clash against Brian Kelly and the LSU Tigers.

After opening the 2025 season shot out of a cannon, the Ole Miss Rebels are off to a hot start with an unblemished record across the first four weeks of the season.

Despite facing adversity with starting quarterback Austin Simmons suffering an ankle injury, the Rebels have received significant contributions from Trinidad Chambliss under center after back-to-back 400-yard performances.

Now, "LSU Week" has officially arrived for the Ole Miss Rebels as the program prepares for a challenge ahead as the heart of Southeastern Conference play arrives.

" It’s always a big challenge. LSU is always a premier program in college football of elite players, elite roster. I always said you’re always going to play really good teams and really good players at LSU. Last three head coaches there have won national championships," Kiffin said on Sunday,

"When can a program ever say that? Got the highest-paid staff in football now. So, it’s really challenging, and we’re going to have to have a great week of preparation to play with these guys."

Courtesy of Ole Miss Rebels Football.

Now, with game-week arriving, the expert computer models are beginning to log predictions for the SEC matchup.

A look into the Week 5 game information, latest betting lines and the ESPN SP+ computer model score prediction.

The Game Information: Week 5 Edition

Matchup: Ole Miss Rebels vs. LSU Tigers
Kickoff Time: 2:30 p.m. CT
Venue: Vaught Hemingway Stadium - Oxford (Miss.)
TV Channel: ABC
Radio: LSU Sports Radio Network
LSU Tigers Record: 4-0 (1-0 SEC)
Ole Miss Rebels Record: 4-0 (2-0 SEC)

Courtesy of Ole Miss Rebels Football.

Odds, Spread and Total: Week 5 Edition

Odds via DraftKings Sportsbook

Spread

• LSU: +2.5 (-115)
• Ole Miss: -2.5 (-105)

Moneyline

• LSU: +105
• Ole Miss: -125

Total

• Over: 55.5 (-112)
• Under 55.5 (-108)

Ole Miss will enter the Week 5 clash as 2.5-point favorites, according to DraftKings Sportsbook.

Courtesy of Ole Miss Rebels Football.

The SP+ Prediction: Rebels Win a Thriller

According to Bill Connelly's SP+ computer model, the Ole Miss Rebels have a 64 percent chance of walking out of Vaught Hemingay Stadium with a victory over the LSU Tigers.

The expert computer model is giving Ole Miss the edge with a final score prediction of 29-23 in the Week 5 matchup.

Ole Miss and LSU will kickoff at 2:30 p.m. CT on ABC with all eyes set to be on the Southeastern Conference showdown between a pair of unbeaten programs

More Ole Miss News:

The Ole Miss Football Depth Chart: Lane Kiffin and Co. Gearing Up for 2025 Season

Ole Miss Football 'Impressing' Texas Longhorns, Ohio State Buckeyes Target

Alabama Head Coach Betting Odds: Ole Miss Football's Lane Kiffin Listed as a Favorite

Join the Community:

Follow Zack Nagy on Twitter: @znagy20 and Ole Miss Rebels On SI: @OleMissOnSI for all coverage surrounding the Ole Miss program.