ESPN's FPI Predicts Outcome of Ole Miss Football vs. LSU Tigers Week 5 SEC Clash

Lane Kiffin and Co. enter the matchup as betting favorites, Vegas riding with the Rebels against LSU.

Courtesy of Ole Miss Rebels Football.

No. 13 Ole Miss (4-0, 2-0 SEC) will return to Vaught Hemingway Stadium in Week 5 for an SEC matchup against Brian Kelly and the LSU Tigers.

Lane Kiffin and Co. are clicking on all cylinders to open the 2025 season with the program flaunting an unblemished record across the first four games of the year.

Despite starting quarterback Austin Simmons suffering an ankle injury in Week 2 at Kentucky, the Rebels have seen an offensive eruption across the last two weeks led by signal-caller Trinidad Chambliss.

Chambliss has pieced together back-to-back 400-yard performances after earning his first career starts with the Rebels.

"I love the most important thing - not turning the ball over two weeks in a row. If you do that, you win a lot of games," Kiffin said on Saturday. "First offense didn’t turn it over back-to-back weeks and he played really clean. No balls on the ground, one sack. We had one last week.

Courtesy of Ole Miss Rebels Football.

"So back to back weeks, when you just don’t have negative plays, and he carries the ball 14 times, only loses two yards. Has the one sack, everything else is positive and rushed for 112. So what, 419 total, in three and a half quarters is really good against a defense that’s stopped a lot of people.”

Now, with a daunting LSU Tigers defense up next on the schedule, Kiffin and Co. are gearing up for a challenging foe in Week 5.

A look into the Week 5 game information, latest betting lines and the ESPN Football Power Index prediction.

The Game Information: Week 5 Edition

Matchup: Ole Miss Rebels vs. LSU Tigers
Kickoff Time: 2:30 p.m. CT
Venue: Vaught Hemingway Stadium - Oxford (Miss.)
TV Channel: ABC
Radio: LSU Sports Radio Network
LSU Tigers Record: 4-0 (1-0 SEC)
Ole Miss Rebels Record: 4-0 (2-0 SEC)

Courtesy of Ole Miss Rebels Football.

Odds, Spread and Total: Week 5 Edition

Odds via DraftKings Sportsbook

Spread

• LSU: +1.5 (-115)
• Ole Miss: -1.5 (-105)

Moneyline

• LSU: -105
• Ole Miss: -115

Total

• Over: 54.5 (-112)
• Under 54.5 (-108)

The Ole Miss Rebels will enter the Week 5 clash as 1.5-point favorites, according to DraftKings Sportsbook.

Courtesy of Ole Miss Rebels Football.

The ESPN Football Power Index Pick: Ole Miss the Favorite

Lane Kiffin and the Ole Miss Rebels will enter Saturday against the LSU Tigers with a 73.3 percent chance of taking home a victory.

The ESPN FPI favors the Rebels in this one with Kiffin and Co. looking to start the 2025 season off to a 5-0 start.

No. 13 Ole Miss and No. 4 LSU will kickoff at 2:30 p.m. CT at Vaught Hemingway Stadium in a critical SEC showdown.

More Ole Miss News:

The Ole Miss Football Depth Chart: Lane Kiffin and Co. Gearing Up for 2025 Season

Ole Miss Football 'Impressing' Texas Longhorns, Ohio State Buckeyes Target

Alabama Head Coach Betting Odds: Ole Miss Football's Lane Kiffin Listed as a Favorite

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