Skip to main content

Ohio State vs. Notre Dame picks, predictions: Week 4 college football odds, spread, lines

Expert picks and predictions for Ohio State vs. Notre Dame in this epic Week 4 college football game
  • Author:
  • Publish date:

One of the most highly-anticipated games of the early season schedule is set to kick off this weekend as No. 6 Ohio State takes it on the road against No. 9 Notre Dame in college football's Week 4 action on Saturday.

The game is a rematch of last season's opener, then also between a pair of ranked teams, with the Buckeyes prevailing in a 21-10 decision on the way to making the College Football Playoff, and this year's game figures to once again have a direct impact on what the final four semifinal could look like.

Sam Hartman has revitalized the Fighting Irish offensive attack as the Wake Forest transfer quarterback has passed for 1,061 yards with 13 touchdowns with no turnovers, while tailback Audric Estime has eclipsed 500 yards rushing and five scores.

Ohio State's offense is still finding its identity, though quarterback Kyle McCord is coming off an efficient performance in a rout over Western Kentucky, and while the Buckeyes boast arguably college football's premier receiving corps, they also present a formidable challenge running the ball.

What do the experts think of the matchup? Let's see how the College Football Power Index computer prediction model projects the game.

Ohio State vs. Notre Dame picks, predictions

Notre Dame Fighting Irish linebacker JD Bertrand at the line of scrimmage during a college football game.

Ohio State vs. Notre Dame picks, predictions

Ohio State odds: The computers project a strong showing from the Buckeyes, who have the 65.8 percent chance to win outright on the road, according to the computer model that picks winners by simulating games 20,000 times.

Notre Dame odds: Conversely, the Fighting Irish have a 34.2 percent chance to defend home turf and pull off the upset, according to the latest simulations.

Point spread: Ohio State comes into the game as close 3.5 point favorites against Notre Dame, according to the lines at SI Sportsbook.

Total: 53.5 points

Moneyline: Ohio State -175, Notre Dame +138

Ohio State predictions: Last week's win nudged the Buckeyes up 1 spot on the index's 133 football rankings to the No. 1 position nationally, based on projections that the team is 27.7 points better than an average opponent, projected to win 11.2 games with a 54.6 percent shot at making the College Football Playoff, based on the simulations.

Notre Dame predictions: Down 3 spots this week despite staying perfect, the Irish are estimated to be 19.7 points better than an average opponent and the index predicts that ND will win 9.7 games this season, with an 11.9 percent shot to make the CFP.

Ohio State vs. Notre Dame schedule

When: Sat., Sept. 23
Where: Notre Dame, Ind.
Time: 7:30 p.m. Eastern
TV: NBC network
Stream live: fuboTV (Try for free)

College Football Power Index

Football Power Index (FPI) college football rankings and computer prediction model are a measure of team strength that predicts a team’s future performance.

Rankings and scores predictions are based on 20,000 simulations of a team’s season and games, using a combination of key analytics, including scores to date, quality of opponents, team talent, recruiting, and a team’s schedule.

Want to bet on Ohio State vs. Notre Dame? Here's how

Join FanDuel here to claim $200 worth of bonus bets after wagering just $5 on any game, including Ohio State vs. Notre Dame.

Claim $200 in Bonus Bets instantly when you Bet $5 with DraftKings as the Buckeyes and Fighting Irish square off.

Get $200 in Bonus Bets with Bet365 here when you Bet Just $1 on any college football game.

Get up to $1,000 in Bonus Bets with Points Bet right here.

Or get $1,500 paid back in bonus bets from BetMGM if you don’t win.

College football rankings

A closer look at the AP top 25

First-place votes in parentheses

  1. Georgia (57)
  2. Michigan (2)
  3. Texas (3)
  4. Florida State (1)
  5. USC
  6. Ohio State
  7. Penn State
  8. Washington
  9. Notre Dame
  10. Oregon
  11. Utah
  12. LSU
  13. Alabama
  14. Oregon State
  15. Ole Miss
  16. Oklahoma
  17. North Carolina
  18. Duke
  19. Colorado
  20. Miami
  21. Washington State
  22. UCLA
  23. Tennessee
  24. Iowa
  25. Florida

More college football from SI: Top 25 Rankings | Schedule | Teams

Follow College Football HQ: Bookmark | Rankings | Picks