Man City and Chelsea meet two weeks after a humbling rout to decide the League Cup champion, while Man United and Liverpool clash in a rematch that will have big implications at the top of the EPL table.
Atletico Madrid and Man City were both on the losing end of VAR calls, but they were on the winning end on the scoreboard, with each taking huge steps toward the Champions League quarterfinals at the expense of Juventus and Schalke, respectively.
Despite all the attacking talent in action, none of Liverpool, Bayern Munich, Lyon and Barcelona could find the back of the net, sending two Champions League last-16 matchups finely poised heading into their second legs.
The signs are getting bleaker for Maurizio Sarri at Chelsea, with the manager's choices continuing to prove costly for the club, while Ole Gunnar Solskjaer's Manchester United bounced back nicely to answer some questions while advancing to the FA Cup quarterfinals.
After humbling defeats that exposed bigger-picture issues, both Man United and Chelsea turn to the FA Cup for a rebound and validation, all while their managers' long-term futures remain in the balance.
Without Harry Kane and Dele Alli, Tottenham blew away Borussia Dortmund with a dominant second half, while Real Madrid was able to escape Ajax with a narrow victory that was aided by technology in the Champions League.
PSG went into Old Trafford without Neymar and Edinson Cavani and had its way with Manchester United, while Roma relied on a 19-year-old to provide the spark in the first leg of the Champions League round of 16.
On Sunday, Man City overwhelmed Chelsea in every department thus highlighting a mesmerizing performance. But Pep Guardiola's side also exposed Chelsea's alarming situation under Maurizio Sarri, placing a question mark on the manager's future with the club.